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US 8,679,479 B2Granted
Methods for purifying pegylated arginase
AssigneeAERase, Inc.
InventorsGeorge Georgiou, Everett Stone
Life of this patent
Estimating the term…
Abstract
Methods and composition for generation of arginase variants with high serum persistence are provided. For example, in certain aspects methods for purifying pegylated arginase are described. Furthermore, the invention provides stabilized arginase multimers or pharmaceutical composition thereof.
Claims9
A method for separating pegylated arginase from unpegylated arginase, comprising:
- a) obtaining a protein solution comprising pegylated arginase and unpegylated arginase;
- and
- b) separating the pegylated arginase by size from the unpegylated arginase at a pH from about 3 to about 5.5.
Dependencies are inferred from the claim text.