Anti-infective agents and/or immunomodulators used for preventive therapy following an acute cerebrovascular accident
AssigneesHans-Dieter Volk, Christian Meisel, Andreas Meisel, Ulrich Dirnagl, Konstantin Prass
InventorsAndreas Meisel, Konstantin Prass, Christian Meisel, Elke Halle, Ulrich Dirnagl, Hans Dieter Volk
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Abstract
The invention refers to agents for the preventive therapy after acute stroke, in particular having the aim to prevent infections after stroke. The agents inventively employed in pharmaceutical preparations are anti-infective agents and/or immunomodulating agents, e.g. cytokines and/or inhibitors of the SNS.
Claims9
A method for treating the development of a bacterial infection after acute stroke in order to reduce lethality and morbidity from pneumonia, urinary tract infection, and/or sepsis,
- wherein said method comprises administering, to a patient who has had a stroke, at least one anti-infective agent comprising at least one antibiotic in a pharmaceutical preparation, wherein said antibiotic is selected from the group consisting of moxifloxacin (1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]-pyridin-6-yl]-4-oxoquinoline-3-carboxylic acid), mezlocillin, sulbactam and combinations thereof;
- and optionally
- at least one immunomodulating agent, and starting the anti-infective therapy within 72 hours following the stroke.
Dependencies are inferred from the claim text.