Methods of treating disorders mediated by histamine H3 receptors using pyridazinone derivatives

A method for palliative treatment of a patient afflicted by a disease or disorder which is narcolepsy, a sleep/wake disorder, attention deficit hyperactivity disorder (ADHD), Alzheimer's disease, schizophrenia, or a cognition/cognitive disorder, comprising administering to the patient in need thereof a therapeutically effective amount of a compound according to formula Ie:

• or a stereoisomeric form, mixture of stereoisomeric forms, or a pharmaceutically acceptable salt thereof, wherein:
• R1 is selected from a piperidinyl or pyrrolidinyl ring, optionally substituted with 1 to 3 R20 groups;
• R12 is H, C1-C6 alkyl, cycloalkyl, aryl, arylalkyl, heteroaryl, heterocycloalkyl, C(═O)R27, or CO2R27, wherein the C1-C6 alkyl, cycloalkyl, aryl, arylalkyl, heteroaryl, or heterocycloalkyl group is optionally substituted with 1 to 3 R20 groups;
• R13 and R14 are each independently H, C1-C6 alkyl, aryl, arylalkyl C1-C6alkoxyl, S(═O)y—C1-C6 alkyl, cycloalkyl, heterocycloalkyl, or heteroaryl;
• or R13 and R14, are taken together with the carbon atoms through which they are connected to form a fused phenyl, thienyl, pyrrolyl, oxazolyl, pyridinyl, cyclopentyl or cyclohexyl ring, wherein the fused phenyl, thienyl, pyrrolyl, oxazolyl, pyridinyl, cyclopentyl or cyclohexyl ring is optionally substituted with 1 to 3 R20 groups;
• R20 at each occurrence is independently, H, F, Cl, Br, I, OR21, NR23R24, NHOH, NO2, CN, CF3, C1-C6 alkyl optionally substituted with OR26, C2-C6 alkenyl, C2-C6 alkynyl, C3-C7 cycloalkyl(C0-C4 alkyl), 3- to 7-membered heterocycloalkyl(C0-C4 alkyl), phenyl, 5- or 6-membered heteroaryl(C0-C4alkyl), arylalkyl, (═O), C(═O)R21, CO2R21, C(═O)R21, C(═O)NR23R24, NR27C(═O) R21, NR27C(═O)OR21, C(═O)NR23R24, NR27C(═OS)R21, or S(O)qR21;
• each R21 is independently H, C1-C6 alkyl, aryl, or arylalkyl;
• each R23 and R24 is independently selected from H, C1-C6 alkyl, and aryl, or R23 and R24, together with the nitrogen atom to which they are attached, form a 3 to 7 membered heterocyclic ring optionally substituted with ═O;
• R26 is H, C1-C6alkyl, aryl, or alkylaryl;
• R27 is H, or C1-C6 alkyl;
• q is 0, 1, or 2;
• and
• y is 0, 1, or 2.