Polypeptoid pulmonary surfactants
AssigneesAnnelise E. Barron, Chiron Corporation
InventorsAnnelise E. Barron, Ronald N. Zuckermann, Cindy W. Wu
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Abstract
The present invention provides spreading agents based on sequence-specific oligomers comprising a peptoid, a peptide-peptoid chimera, a retropeptoid or a retro(peptoid-peptide) chimera, and methods for using the same, including for the treatment of respiratory distress of the lungs. The spreading agents are sequence-specific oligomers, including retrosequence-specific oligomers, based on a peptide backbone, that are designed as analogs of surfactant protein-B or surfactant protein-C.
Claims16
An SP-C mimic compound comprising an N-terminal component of 2 residues selected from N-substituted glycine residues Noc, Npm and Nhd, and Phe and combinations thereof;
- a sequence selected from peptide sequence ProValHisLeuLysArg (SEQ ID NO:
- 1) and biomimetic sequences thereof wherein said biomimetic sequences are peptide sequences of SEQ ID NO:
- 1 wherein at least one peptide sequence residue of SEQ ID NO:
- 1 is replaced with an N-substituted glycine residue, said N-substituent is the α-carbon sidechain moiety of said replaced peptide sequence residue;
- and a hydrophobic C-terminal component of said compound of about 12 to about 20 N-substituted glycine residues selected from Npm, Nspe and Nssb residues and combinations thereof.
An SP-C mimic compound comprising an N-terminal component of 2 residues selected from N-substituted glycine residues Noc, Npm and Nhd and combinations thereof;
- a biomimetic peptoid sequence NproNValNHisNLeuNLysNArg;
- and a hydrophobic C-terminal component of said compound of about 12 to about 20 N-substituted glycine residues selected from Npm, Nspe and Nssb residues and combinations thereof.
An SP-C mimic compound comprising an N-terminal component of 2 residues selected from N-substituted glycine residues Noc,Npm and Nhd and combinations thereof;
- a biomimetic peptoid sequence NProNValNHisNLeuNLysNArg;
- and a hydrophobic C-terminal component of said compound of 12 to 14 N-substituted glycine residues selected from Npm, Nspe and Nssb residues and combinations thereof.
Dependencies are inferred from the claim text.