Synthetic viruses and uses thereof
AssigneeL'Universite Pierre Et Marie Curie
InventorsDavid Klatzmann, Jean-Loup Salzmann, Bertrand Bellier, Charlotte Frisen, François-Loïc Cosset
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Abstract
The present invention relates to compositions and methods for producing an immune response or reaction, as well as to vaccines, kits, processes, cells and uses thereof. This invention more particularly relates to compositions and methods of using a synthetic viral particle to produce, modify or regulate an immune response in a subject. In a more preferred embodiment, the invention is based, generally, on compositions using synthetic viral particles as an adjuvant and/or vehicle to raise an immune response against selected antigen(s) or epitopes, in particular a cellular and/or a humoral immune response.
Claims21
An immunogenic composition comprising a non-infectious synthetic retroviral particle comprising:
- a core comprising at least one self-assembling retroviral Gag protein of a particular retrovirus that is fused in-frame with a heterologous peptide antigen;
- and a lipid bilayer envelope;
- wherein the non-infectious synthetic retroviral particle is devoid of any retroviral genome;
- wherein the non-infectious synthetic retroviral particle is devoid of wild-type infectious envelope protein of the particular retrovirus;
- and wherein the immunogenic composition comprises at least about 10^2 to about 10^9 of the synthetic retroviral particles.
An immunogenic composition comprising a non-infectious synthetic retroviral particle comprising:
- a core comprising a self-assembling retroviral Gag protein of a particular retrovirus that is fused in-frame with a first heterologous peptide antigen;
- and a lipid bilayer envelope in which a second selected peptide antigen that is heterologous to any retrovirus is embedded and exposed at the surface of the particle;
- wherein the non-infectious synthetic retroviral particle is devoid of any retroviral genome;
- wherein the non-infectious synthetic retroviral particle is devoid of wild-type infectious envelope protein of the particular retrovirus:
- and wherein the immunogenic composition comprises at least about 10^2 to about 10^9 of the synthetic retroviral particles.
Dependencies are inferred from the claim text.