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AssigneeBASF SE
InventorsHartwig Schroder, Stefan Haefner, Gregory Von Abendroth, Rajan Hollmann, Aline Raddatz, Hansgeorg Ernst, Hans Gurski
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The present invention relates to bacterial strains, capable of utilizing glycerol as a carbon source for the fermentative production of succinic acid, wherein said strains are genetically modified so that they comprise a deregulation of their endogenous pyruvate-formate-lyase enzyme activity, as well as to methods of producing organic acids, in particular succinic acid, by making use of such microorganism. The present invention also relates to the downstream processing of the produced organic acids by cation exchange chromatography.
A bacterial strain, capable of utilizing glycerol as the only carbon source for the fermentative production of succinic acid, wherein said strain is genetically modified so that it comprises a deregulation of its endogenous pyruvate-formate-lyase enzyme activity, wherein said pyruvate-formate-lyase enzyme activity is decreased or “switched-off, and wherein said strain is derived from a microorganism of the family of Pasteurellaceae and comprises the 16S rDNA sequence of SEQ ID NO:
A bacterial strain, capable of utilizing glycerol as a carbon source for the fermentative production of succinic acid, wherein said strain is genetically modified so that it comprises a deregulation of its endogenous pyruvate-formate-lyase enzyme activity, wherein said pyruvate-formate-lyase enzyme activity is decreased or switched-off, and wherein said strain is derived from strain DD1 as deposited with DSMZ having the deposit number DSM 18541.
Dependencies are inferred from the claim text.