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US 8,673,555 B2Granted
Detecting neoplasm
AssigneeMayo Foundation for Medical Education and Research
InventorsWilliam R. Taylor, Jonathan J. Harrington, Patrick S. Quint, Hongzhi Zou, Harold R. Bergen, III, David I. Smith, David A. Ahlquist
Life of this patent
Estimating the term…
Abstract
This document relates to methods and materials for detecting premalignant and malignant neoplasms. For example, methods and materials for determining whether or not a stool sample from a mammal contains nucleic acid markers or polypeptide markers of a neoplasm are provided.
Claims8
A method of detecting colorectal cancer or pre-cancer in a mammal, said method comprising:
- a) obtaining a stool sample from a mammal;
- and
- b) measuring a K-ras mutation score within said stool sample, measuring BMP3 methylation status within said stool sample, and measuring the level of human DNA within said stool sample,
- wherein measurement of an elevated K-ras mutation score, elevated BMP methylation status, and elevated human DNA level as compared to a normal control indicates that said mammal has said colorectal cancer or pre-cancer.
1 more element
A method of detecting aero-digestive cancer or pre-cancer in a mammal, said method comprising;
- a) obtaining a stool sample from a mammal;
- and
- b) measuring a K-ras mutation score within said stool sample, measuring BMP3 methylation status within said stool sample, and measuring the level of human DNA within said stool sample,
- wherein measurement of an elevated K-ras mutation score, elevated BMP methylation status, and elevated human DNA level as compared to a normal control indicates that said mammal has said aero-digestive cancer or pre-cancer.
1 more element
Dependencies are inferred from the claim text.