Halogenated phenols for diagnostics, antioxidant protection and drug delivery
OwnerKeith R. Lathaminventor
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Abstract
The present invention relates to a composition and method for the detection of a detectable product formed from a compound of the present invention in the body of an individual. The detectable product may include a halide or a benzenetriol-based or benzenetetrol-based product of a dehalogenation reaction in the presence of FROS. In many embodiments, an indigo-like product formed from an indigogenic compound of the present invention may also be a detectable product for diagnostic purposes. This indigo-like product may have a higher residence time in tissues where it is formed, thus providing a detectable product localized to sites of high FROS. An indigogenic compound containing one or more radioactive isotopes is further provided for therapeutic purposes.
Claims27
A composition comprising a compound having the following chemical structure:
- wherein R1, R2, R3, R4, R5, R6 and R7 are each a hydrogen, a hydroxyl, a sulfhydryl, an alkyl, a halogen, an amino, or a nitro group, and wherein X is a halogen.
A method comprising:
- (a) administering to an individual having cancer a composition comprising a compound having the following chemical structure:
- wherein R1, R2, R3, R4, R5, R6 and R7 are each a hydrogen, a hydroxyl, a sulfhydryl, an alkyl, a halogen, an amino, or a nitro group,
- wherein X is a halogen, and
- wherein one or more of R1, R2, R3 and R4 contains a radioactive isotope.
Dependencies are inferred from the claim text.