Methods of using water-soluble inorganic compounds for implants
AssigneeAMx Tek LLC
InventorJames A. Walls
Life of this patent
Estimating the term…
Abstract
A method for controlling generation of biologically desirable voids in a composition placed in proximity to bone or other tissue in a patient by selecting at least one water-soluble inorganic material having a desired particle size and solubility, and mixing the water-soluble inorganic material with at least one poorly-water-soluble or biodegradable matrix material. The matrix material, after it is mixed with the water-soluble inorganic material, is placed into the patient in proximity to tissue so that the water-soluble inorganic material dissolves at a predetermined rate to generate biologically desirable voids in the matrix material into which bone or other tissue can then grow.
Claims45
A method for controlling generation of biologically desirable voids in a composition placed in proximity to tissue in a patient, comprising:
- selecting at least one water-soluble inorganic material capable of resisting degradation when subjected to sterilization temperatures, remaining water soluble and biologically functional after being subjected to sterilization temperatures, having at least one sintering temperature and having at least a first average particle dimension and a desired dissolution rate;
- selecting a poorly-water-soluble matrix material having a physically continuous interconnected matrix as a porous structure disposed on at least a portion of the outer surface of an implant and defining interstices within the porous structure, wherein the first average particle dimension is selected to be smaller than the average dimension of the interstices;
- blending the water-soluble inorganic material within at least some of the interstices of the porous structure;
- attaching the water-soluble inorganic material within the interstices to form the composition on the implant, the attaching including heating to the at least one sintering temperature;
- and
- placing the implant carrying the composition into the patient in proximity to tissue so that the water-soluble inorganic material progressively dissolves at a predetermined rate to generate biologically desirable voids by gradually exposing more of the interstices into which tissue can then grow to assist fixation of the implant within the patient.
A method for controlling generation of biologically desirable voids in a composition placed in proximity to tissue in a patient, comprising:
- selecting at least one water-soluble inorganic material having at least a first average particle dimension and a desired dissolution rate;
- selecting a poorly-water-soluble matrix material having a physically continuous interconnected matrix as a porous structure disposed on at least a portion of the outer surface of an implant and defining interstices within the porous structure, wherein the first average particle dimension is selected to be smaller than the average dimension of the interstices;
- blending the water-soluble inorganic material within at least some of the interstices of the porous structure;
- attaching the water-soluble inorganic material within the interstices by sintering the water-insoluble inorganic material to the matrix material to form the composition on the implant;
- and
- placing the implant carrying the composition into the patient in proximity to tissue so that the water-soluble inorganic material progressively dissolves at a predetermined rate to generate biologically desirable voids by gradually exposing more of the interstices into which tissue can then grow to assist fixation of the implant within the patient.
A method for controlling generation of biologically desirable voids in a composition placed in proximity to tissue in a patient, comprising:
- selecting at least one water-soluble inorganic material capable of resisting degradation when subjected to sterilization temperatures, remaining water soluble and biologically functional after being subjected to sterilization temperatures including remaining therapeutically effective after withstanding temperatures in excess of 400 degrees Celsius, and having at least a first average particle dimension and a desired dissolution rate;
- selecting a poorly-water-soluble matrix material having a physically continuous interconnected matrix as a porous structure disposed on at least a portion of the outer surface of an implant and defining interstices within the porous structure, wherein the first average particle dimension is selected to be smaller than the average dimension of the interstices;
- blending the water-soluble inorganic material within at least some of the interstices of the porous structure;
- attaching the water-soluble inorganic material within the interstices to form the composition on the implant, the attaching including heating to a temperature in excess of 400 degrees Celsius;
- and
- placing the implant carrying the composition into the patient in proximity to tissue so that the water-soluble inorganic material progressively dissolves at a predetermined rate to generate biologically desirable voids by gradually exposing more of the interstices into which tissue can then grow to assist fixation of the implant within the patient.
Dependencies are inferred from the claim text.