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US 8,669,249 B2Granted
Poly (ADP-ribose) polymerase (PARP) inhibitors
AssigneeTakeda Pharmaceutical Company Limited
InventorsJason W. Brown, Anthony R. Gangloff, Andrew John Jennings, Phong H. Vu
Life of this patent
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Abstract
Compounds of the following formula are provided for use in inhibiting Poly (ADP-ribose) Polymerase (PARP): wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds.
Claims12
A compound of the formula:
- a tautomer thereof, or a pharmaceutically acceptable salt of the compound or tautomer, wherein:
- X is O;
- R1 is -L1-R9;
- R2 is selected from the group consisting of hydrogen, halo, and (C1-3)alkyl;
- R3 is selected from the group consisting of hydrogen, halo, hydroxy, (C1-3)alkyl, (C1-3)alkoxy, and aryl(C1-10)alkyl;
- R4 is selected from the group consisting of hydrogen, halo, and (C1-3)alkyl;
- R5 is methyl;
- R6 is hydrogen;
- R7 is selected from the group consisting of hydrogen, halo, and (C1-3)alkyl;
- L1 is selected from the group consisting of —CH2— and;
- R9 is selected from the group consisting of
- R16 and R17 are each independently selected from the group consisting of (C3-12)cycloalkyl, hetero(C3-12)cycloalkyl, (C9-12)bicycloalkyl, hetero(C3-12)bicycloalkyl, (C6-12)aryl, (C1-10)heteroaryl, (C9-12)bicycloaryl and hetero(C4-12)bicycloaryl, each unsubstituted or substituted through available valencies with one or more substituents independently selected from the group consisting of halo, nitro, cyano, oxo, hydroxy, (C1-10)alkoxy, carbonyl, amido, amino, (C1-10)alkyl, halo(C1-10)alkyl, sulfonyl(C1-10)alkyl, and (C6-12)aryl, wherein carbonyl, amido, and amino are each independently substituted with hydrogen, hydroxy, (C1-10)alkoxy, (C1-10)alkyl, (C3-12)cycloalkyl, hetero(C3-12)cycloalkyl or (C6-12)aryl.
9 more elements
Dependencies are inferred from the claim text.