Compositions and methods for lowering triglycerides without raising LDL-C levels in a subject on concomitant statin therapy
AssigneeAmarin Pharmaceuticals Ireland Limited
InventorsIan Osterloh, Pierre Wicker, Rene Braeckman, Paresh Soni, Mehar Manku
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Abstract
In various embodiments, the present invention provides compositions and methods for treating and/or preventing cardiovascular-related diseases in subject in need thereof.
Claims13
A method of lowering triglycerides in a subject having mixed dyslipidemia on stable statin therapy having baseline fasting triglycerides of about 200 mg/dl to about 500 mg/dl, the method comprising orally administering to the subject daily a pharmaceutical composition comprising about 4 g of ethyl eicosapentaenoate and not more than about 4% docosahexaenoic acid or its esters, by weight of all fatty acids, for a period of at least about 4 weeks.
A method of lowering triglycerides in a subject on stable statin therapy having baseline fasting triglycerides of about 200 mg/dl to about 500 mg/dl and an LDL-C level of 40 mg/dl to 100 mg/dl, the method comprising orally administering to the subject daily a pharmaceutical composition, present more than one dosage unit, comprising about 4 g of ethyl eicosapentaenoate and not more than about 4% docosahexaenoic acid or its esters, by weight of all fatty acids, for a period of at least about 4 weeks.
Dependencies are inferred from the claim text.