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US 8,668,926 B1Granted
Nanoparticle and polymer formulations for thyroid hormone analogs, antagonists, and formulations thereof
OwnerShaker A. Mousa, Faith B. Davis +1inventors
InventorsShaker A. Mousa, Faith B. Davis, Paul J. Davis
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Abstract
Disclosed are methods of treating subjects having conditions related to angiogenesis including administering an effective amount of a polymeric Nanoparticle form of thyroid hormone agonist, partial agonist or an antagonist thereof, to promote or inhibit angiogenesis in the subject. Compositions of the polymeric forms of thyroid hormone, or thyroid hormone analogs, are also disclosed.
Claims6
A method for treating a non-cancerous skin disorder comprising:
- providing a thyroid hormone analog conjugated to a polymer via a linker, wherein the polymer is poly(lactic-co-glycolic) acid (PLGA), polylactide, polyglycolide, or co-polymers thereof, wherein said thyroid hormone analog is selected from the group consisting of tetraiodothyroacetic acid (TETRAC), triiodothyroacetic acid (TRIAC), thyroid antagonists and combinations thereof, wherein the linker is an ester linkage, anhydride linkage, thioether linkage, sulfhydryl linkage or ether linkage, wherein the conjugated thyroid hormone analog acts exclusively at the cell surface receptor and the conjugated thyroid hormone analog is a sufficient size to prevent the conjugated thyroid hormone analog from entering the cell;
- and
- administering the thyroid hormone analog conjugated to a polymer via a linker to a portion of the skin affected by the non-cancerous skin disorder.
Dependencies are inferred from the claim text.