Organic compounds

A Compound of Formula I-A or I-B

• wherein
• (i) Q is C(═O), C(═S), C(═N(R20)) or CH2;
• (ii) L is a single bond, —N(H)—, —CH2—, —S—, —S(O)— or —S(O2)—;
• (iii) R1 is H or C1-4 alkyl;
• (iv) R4 is H or C1-6 alkyl and R2 and R3 are, independently, H or C1-6alkyl optionally substituted with halo or hydroxy, aryl, heteroaryl, (optionally hetero)arylalkoxy, or (optionally hetero)arylC1-6alkyl;
• or
• R2 is H and R3 and R4 together form a di-, tri- or tetramethylene bridge;
• (v) R5 is
• a) -D-E-F, wherein:
• D is C1-4alkylene;
• E is a single bond, C2-4alkynylene, arylene or heteroarylene;
• F is H, aryl, heteroaryl, halo, haloC1-4alkyl, —C(O)—R15, —N(R16)(R17), or C3-7cycloalkyl optionally containing at least one atom selected from a group consisting of N or O;
• wherein D, E and F are independently and optionally substituted with one or more halo, C1-4alkyl, haloC1-4alkyl;
• or
• b) a haloalkyl substituted heteroarylalkyl;
• or
• c) attached to the nitrogen on the pyrrolo portion of Formula I-A or I-B and is a moiety of Formula A
• wherein X, Y and Z are, independently, N or C, and R8, R9, R11 and R12 are independently H or halogen, and R10 is halogen, C1-4alkyl, C3-7cycloalkyl, C1-4haloalkyl, aryl, heteroaryl, arylcarbonyl, alkylsulfonyl, heteroarylcarbonyl, or alkoxycarbonyl;
• provided that when X, Y, or Z is nitrogen, R8, R9, or R10, respectively, is not present;
• (vi) R6 is
• H,
• C1-4alkyl,
• C3-7cycloalkyl,
• aryl,
• heteroaryl,
• arylC1-4alkyl,
• arylamino,
• heteroarylamino,
• N,N-diC1-4alkylamino,
• N,N-diarylamino,
• N-aryl-N-(arylC1-4alkyl)amino, or
• —N(R18)(R19);
• wherein the aryl or heteroaryl is optionally substituted with one or more halo, hydroxy or C1-6alkoxy;
• (vii) R7 is H, C1-6alkyl, halogen, or —N(R18)(R19);
• (viii) n=0 or 1;
• (ix) when n=1, A is —C(R13R14)—, wherein R13 and R14, are, independently, H or C1-4alkyl, aryl, heteroaryl, (optionally hetero)arylC1-4alkoxy or (optionally hetero)arylC1-4alkyl;
• (x) R15 is C1-4alkyl, haloC1-4alkyl, —OH or —OC1-4alkyl;
• (xi) R16 and R17 are independently H or C1-4alkyl;
• (xii) R18 and R19 are independently H, C1-4alky or aryl wherein said aryl is optionally substituted with one or more halo or hydroxy;
• (xiii) R20 is H, C1-4alkyl or C3-7cycloalkyl,
• in free or salt form.