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US 8,664,192 B2Granted
Mutator activity induced by microRNA-155 (miR-155) links inflammation and cancer
AssigneeThe Ohio State University
InventorCarlo M. Croce
Life of this patent
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Abstract
Methods of reducing spontaneous mutation rate of a cell in a subject in need thereof by reducing endogenous levels of miR-155 are described.
Claims26
A method for modulating WEE1 kinase expression levels in an inflammation-related solid cancer target cell, comprising:
- administering a microRNA-155 (miR-155) antagonist to the target cell in an amount sufficient to modulate WEE1 kinase levels, and wherein the WEE1 levels are increased after administration.
A method of reducing spontaneous mutation rate of an inflammation-related solid cancer target cell in a subject in need thereof, comprising:
- contacting the target cell with an antisense miR-155 inhibitory RNA (155-I) in an amount sufficient to increase WEE1 levels, wherein the WEE1 levels are increased after 155-I treatment.
A method of preventing the onset of an inflammatory-related breast cancer, comprising:
- normalizing WEE1 levels by reducing inflammatory-related up-regulation of miR-155 in a subject in need thereof, by administering an antisense miR-155 inhibitory RNA (155-I) to a breast cell such that the resulting expression of miR-155 is normalized or elevated by no more than two-fold as compared with a control level of miR-155 expression, and wherein WEE1 levels are increased after 155-I treatment.
Dependencies are inferred from the claim text.