Microfluidic chip capable of synthesizing radioactively labeled molecules on a scale suitable for human imaging with positron emission tomography
AssigneesSiemens Medical Solutions USA, Inc., California Institute of Technology
InventorsArkadij M. Elizarov, Hartmuth C. Kolb, R. Michael Van Dam, James R. Heath
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Abstract
Described herein are automated, integrated microfluidic device comprising a chemical reaction chip comprising for performing chemical reaction, a microscale column integrated with the chip and configured for liquid flow from the column to at least one flow channel, and wherein the fluid flow into the column is controlled by on-chip valves; and comprising at least two on-chip valves for controlling fluid flow in the microfluidic device.
Claims18
A microfluidic device for performing chemical reactions, the device comprising:
- a microfluidic chip comprising:
- i) a reaction chamber;
- ii) at least one substantially flat channel located below the reaction chamber to control fluid flow through the reaction chamber;
- iii) a network of one or more inlet flow channels and one or more outlet flow channels, wherein each inlet flow channel and each outlet flow channel is equipped with at least two on-chip valves for controlling the fluid flow of reagents, solvents and reaction products to and from the reaction chamber;
- and
- iv) a vent adjacent to the reaction chamber, wherein the vent comprises at least one radiator channel having a winding shape and being separated from the reaction chamber by a gas permeable membrane, the membrane and the radiator channels being above the reaction chamber.
A microfluidic chip comprising:
- a reaction chamber;
- at least one substantially flat channel located below the reaction chamber to control fluid flow through the reaction chamber;
- a network of one or more inlet flow channels and one or more outlet flow channels equipped with associated valves, the associated valves being configured for controlling the flow of reagents, solvents and reaction products to and from the reaction chamber;
- and
- a vent adjacent to the reaction chamber, wherein the vent comprises a radiator of channels having a winding shape and being separated from the reaction chamber by a gas permeable membrane, the membrane and the radiator channels being above the reaction chamber.
Dependencies are inferred from the claim text.