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US 8,652,487 B2Granted
Tolerogenic synthetic nanocarriers for inducing regulatory B cells
AssigneeSelecta Biosciences, Inc.
InventorRoberto A. Maldonado
Life of this patent
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Abstract
Disclosed are synthetic nanocarrier methods, and related compositions, comprising B cell and/or MHC Class II-restricted epitopes and immunosuppressants in order to generate tolerogenic immune responses, such as the generation of antigen-specific regulatory B cells.
Claims13
A method for generating antigen-specific regulatory B cells that produce IL-10 in a mammalian subject, comprising:
- administering to the mammalian subject a composition that comprises:
- (i) a first population of synthetic nanocarriers coupled to immunosuppressants, and
- (ii) a second population of synthetic nanocarriers coupled to antigens that comprise B cell epitopes and/or MHC Class II-restricted epitopes,
- wherein the composition is in an amount effective to generate antigen-specific regulatory B cells that produce IL-10 in the subject, and assessing the generation of antigen-specific regulatory B cells that produce IL-10 in the subject prior to and/or after the administration of the composition.
1 more element
A method for generating antigen-specific regulatory B cells that produce IL-10 in a mammalian subject, comprising:
- administering to the mammalian subject a composition according to a protocol that was previously shown to generate antigen-specific regulatory B cells that produce IL-10 in one or more test subjects;
- wherein the composition comprises:
- (i) a first population of synthetic nanocarriers coupled to immunosuppressants, and
- (ii) a second population of synthetic nanocarriers coupled to antigens that comprise B cell epitopes and/or MHC Class II-restricted epitopes.
1 more element
Dependencies are inferred from the claim text.