Fluorescence sensor, needle-type fluorescence sensor, and method for measuring analyte

A needle-type fluorescence sensor that penetrates a living body, the needle-type fluorescence sensor comprising:

• a needle body section including a sensor portion disposed in a needle distal end portion that indwells in the living body and a plurality of metal lines disposed from the sensor portion to a needle proximal end portion;
• and
• a connector which is integrated with the needle body section and in which the plurality of metal lines extend,
• the sensor portion including
• a base member having first and second principal surfaces, the base member comprising silicon,
• a photoelectric conversion device that is formed on the first principal surface of the base member and converts fluorescence into an electrical signal;
• a light emitting diode device that emits excitation light disposed above the photoelectric conversion device, and
• an indicator layer that interacts with an analyte in the living body under the excitation light to produce fluorescence, the indicator layer disposed above the light emitting diode device,
• wherein the photoelectric conversion device, the light emitting diode device, and the indicator layer overlap with each other above the first principal surface of the base member, and the fluorescence produced in the indicator layer passes through the light emitting diode device and impinges on the photoelectric conversion device.

A method for measuring an analyte by using a fluorescence sensor, the method comprising:

• an excitation light irradiation step in which excitation light emitted from a light emitting diode device is introduced into an indicator layer, the indicator layer disposed above the light emitting diode device, the light emitting diode device disposed above a first principal surface of a base member, the base member having a first principal surface and a second principal surface, the base member comprising silicon;
• a fluorescence emission step in which the indicator layer interacts with the analyte under the excitation light to produce fluorescence;
• and
• a photoelectric conversion step in which the fluorescence produced in the indicator layer passes through the light emitting diode device, impinges on a photoelectric conversion device that is formed on the first principal surface of the base member, and is converted into an electric signal.