Association of the progesterone receptor with fertility
AssigneeWisconsin Alumni Research Foundation
InventorHasan Khatib
Life of this patent
Estimating the term…
Abstract
A single nucleotide polymorphic site at position 59752 of the bovine PGR gene is associated with improved fertilization rate or early embryo survival. Disclosed are nucleic acid molecules, kits, methods of genotyping and marker assisted bovine breeding methods.
Claims15
A dairy cattle breeding method for desirable fertilization rate or early embryo survival rate, or both, the method comprising detecting a guanine at a nucleotide of the PGR gene of a dairy cattle cell or tissue corresponding to position 2752 of SEQ ID NO:
- 1, and using said cell or tissue for breeding purposes.
A method for selectively breeding of cattle the method comprising superovulating a female animal, collecting eggs from said superovulated female, in vitro fertilizing said eggs with semen from a suitable male animal, culturing said fertilized eggs into developing embryos, determining the identity of a nucleotide of the PGR gene of a developing embryo corresponding to position 2752 of SEQ ID NO:
- 1, and planting a developing embryo into a suitable female only if the PRG gene of the developing embryo has G at the position of the PGR gene corresponding to position 2752 of SEQ ID NO:
- 1.
A method for selectively breeding dairy cattle, comprising selecting a bull that is homozygously G at a position of the PGR gene corresponding to position 2752 of SEQ ID NO:
- 1 and using its semen for fertilizing a female animal.
A method for selectively breeding dairy cattle for desirable fertilization rate or early embryo survival rate, or both, comprising selecting a female animal whose PRG gene is homozygously guanine at a position corresponding to position 2752 of SEQ ID NO:
- 1, and fertilizing eggs from the female animal with semen from a suitable bull.
Dependencies are inferred from the claim text.