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US 8,642,802 B2Granted
Process for the preparation of halogenated benzoic acid derivatives
AssigneeHoffmann-La Roche Inc.
InventorsStephan Bachmann, Stefan Hildbrand, James Jappy, Dinesh Maganbhai Patel, Christophe Pfleger, Robert John Ernest Tidswell, Rene Trussardi
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Abstract
The present invention comprises a process for the preparation of 3-chloro-2-fluoro-5-trifluoromethyl benzoic acid of the formula or of a salt thereof 3-Chloro-2-fluoro-5-trifluoromethyl benzoic acid or salts thereof are versatile intermediates for the preparation of active pharmaceutical or agrochemical agents.
Claims8
A process for the preparation of 3-chloro-2-fluoro-5-trifluoromethyl benzoic acid of the formula
- or of a salt thereof, comprising the steps of
- a) transforming the 3-chloro-4-fluoro-benzo trifluoride of formula II,
- into the 3-chloro-2-fluoro-5-trifluoromethyl benzaldehyde of formula III,
- and
- b) oxidizing the 3-chloro-2-fluoro-5-trifluoromethyl benzaldehyde with an oxidant to form the 3-chloro-2-fluoro-5-trifluoromethyl benzoic acid of formula I or of a salt thereof.
2 more elements
Dependencies are inferred from the claim text.