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US 8,642,766 B2Granted
Synthesis of (+) cortistatin A and related compounds
OwnerRyan A. Shenvi, Carlos A. Guerrero +3inventors
InventorsRyan A. Shenvi, Carlos A. Guerrero, Jun Shi, Chuang-Chuang Li, Phil S. Baran
Life of this patent
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Abstract
An in vitro synthesis of (+) cortistatin A from readily available precursors is disclosed, as are the syntheses of related 17-aryl substituted compounds, the 17-aryl substituted compounds themselves and novel compounds useful in their preparation.
Claims7
A compound whose structure corresponds to Formula XII,
- wherein
- R1 is hydrido (H), a straight chain, branched chain or cyclic alkyl, alkenyl, or alkynyl moiety, an aromatic, heterocyclic or alicyclic moiety that contains one to about 24 carbon atoms, in which a heterocyclic moiety contains 1 to four rings that each contain up to four ring atoms other than carbon that can be oxygen, nitrogen or sulfur;
- R5 is hydrido (H), a straight chain, branched chain or cyclic alkyl, alkenyl, or alkynyl moiety, an aromatic, heterocyclic or alicyclic moiety that contains one to about 24 carbon atoms, in which a heterocyclic moiety contains 1 to four rings that each contain up to four ring atoms other than carbon that can be oxygen, nitrogen or sulfur;
- and
- the circled X is a heterocyclic substituent that contains 4 to about 15 carbon atoms, contains one to three saturated or unsaturated rings and up to three atoms per ring that are other than carbon and can be oxygen, nitrogen or sulfur.
2 more elements
A method of preparing a compound whose structure corresponds to Formula XII that comprises
- 1) reacting a compound whose structure corresponds to Formula XI
- wherein
- R1 is hydrido (H), a straight chain, branched chain or cyclic alkyl, alkenyl, or alkynyl moiety, an aromatic, heterocyclic or alicyclic moiety that contains one to about 24 carbon atoms, in which a heterocyclic moiety contains 1 to four rings that each contain up to four ring atoms other than carbon that can be oxygen, nitrogen or sulfur;
- and
- R5 is hydrido (H), a straight chain, branched chain or cyclic alkyl, alkenyl, or alkynyl moiety, an aromatic, heterocyclic or alicyclic moiety that contains one to about 24 carbon atoms, in which a heterocyclic moiety contains 1 to four rings that each contain up to four ring atoms other than carbon that can be oxygen, nitrogen or sulfur, with a trimethyltin derivative of a circled X moiety that is a heterocyclic substituent that contains 4 to about 15 carbon atoms, contains one to three saturated or unsaturated rings and up to three atoms per ring that are other than carbon and can be oxygen, nitrogen or sulfur to form a compound whose structure corresponds to Formula XII,
- wherein R1 and R5 are as defined for a compound whose structure corresponds to Formula XI.
3 more elements
Dependencies are inferred from the claim text.