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US 8,636,982 B2Granted
Wax foamable vehicle and pharmaceutical compositions thereof
AssigneeFoamix Ltd.
InventorsDov Tamarkin, Rita Keynan, David Schuz, Tal Berman
Life of this patent
Estimating the term…
Abstract
Unique foamable vehicles or carriers comprising at least one wax, waxy substance, counterpart or derivative, a stabilizer, water, and a propellant are provided. In some embodiments, the wax is a liquid wax. In some embodiments, the wax includes a solid wax and a liquid wax. The compositions are substantially free of crystals. The components are selected to provide a composition that is substantially resistant to aging and to phase separation, and/or can substantially solubilize and or stabilize active ingredients. Pharmaceutical and cosmetic compositions with potentially enhanced skin delivery and their uses are also provided.
Claims57
A foamable emulsion composition comprising:
- A. a carrier comprising:
- a. a liquid wax comprising at least one fatty acid or at least one fatty alcohol;
- b. a stabilizer component comprising a non ionic surface-active agent;
- c. water;
- and
- d. more than 7% by weight of a solid wax of the carrier selected from the group consisting of a fatty acid, a fatty alcohol, a microcrystalline wax, a paraffin wax, a petroleum wax, a polyethylene wax, beeswax, candelilla wax, castor wax, Chinese wax, Fischer-Tropsch wax, rice bran wax, tallow, wool wax and mixtures thereof;
- and
- B. a liquefied hydrocarbon gas propellant at a concentration of about 3% to about 35% by weight of the foamable emulsion composition;
- wherein, when the liquid wax comprises at least one fatty acid, the fatty acid is present in the composition at a concentration of more than 35% or about 35% by weight of the carrier;
- wherein, when the liquid wax comprises at least one fatty alcohol, the fatty alcohol is present in the composition at a concentration of more than 12% or about 12% by weight of the carrier;
- wherein the liquid wax enables the solid wax to solubilize;
- wherein the composition is substantially free from crystals and is sufficiently flowable;
- wherein the carrier being otherwise free of polymeric agent;
- and
- wherein, upon release from a pressurized container, a breakable foam is produced.
12 more elements
A foamable emulsion composition comprising:
- A. a carrier comprising:
- a. more than 10% or about 10% by weight of the carrier of a solid wax selected from the group consisting of a fatty acid, a fatty alcohol, a microcrystalline wax, a paraffin wax, a petroleum wax, a polyethylene wax, beeswax, candelilla wax, castor wax, Chinese wax, Fischer-Tropsch wax, rice bran wax, tallow, wool wax and mixtures thereof;
- b. a liquid wax wherein the liquid wax comprises at least one fatty acid or at least one fatty alcohol;
- c. a stabilizer comprising a non ionic surface-active agent, a polymeric agent or a mixture thereof;
- d. water;
- and
- B. a liquefied hydrocarbon gas propellant at a concentration of about 3% to about 35% by weight of the foamable emulsion composition;
- wherein the liquid wax enables the solid wax to solubilize;
- wherein the composition is substantially free from crystals and is sufficiently flowable;
- wherein, when the stabilizer component comprises a polymeric agent, the polymeric agent is present in the composition at a concentration of about 0.01% to about 5% by weight of the carrier and is selected from the group consisting of a bioadhesive agent, a gelling agent, a film forming agent and a phase change agent;
- and
- wherein, upon release from a pressurized container, a breakable foam is produced.
9 more elements
The foamable emulsion composition of claim h wherein the liquid wax is a fatty acid or fatty alcohol having 16-22 carbon atoms in its carbon backbone.
A foamable emulsion composition comprising:
- A. a carrier comprising:
- a. about 20% to about 60% by weight of the carrier of isostearic acid;
- b. a solid wax selected from the group consisting of a fatty acid and a fatty alcohol and mixtures thereof;
- c. a non ionic surface-active agent;
- d. imiquimod;
- and
- e. water;
- and
- B. a liquefied hydrocarbon gas propellant at a concentration of about 3% to about 35% by weight of the foamable emulsion composition;
- wherein the carrier being otherwise free of polymeric agent;
- and
- wherein, upon release from a pressurized container, a breakable foam is produced.
9 more elements
A foamable emulsion composition comprising:
- A. a carrier comprising
- a. a liquid wax comprising at least one fatty acid or at least one fatty alcohol;
- b. a stabilizer component comprising a non ionic surface-active agent;
- c. water;
- and
- d. more than 7% by weight of the carrier of a solid wax selected from the group consisting of a fatty acid, a fatty alcohol, a microcrystalline wax, a paraffin wax, a petroleum wax, a polyethylene wax, beeswax, candelilla wax, castor wax, Chinese wax, Fischer-Tropsch wax, rice bran wax, tallow, wool wax and mixtures thereof;
- and
- B. a liquefied hydrocarbon gas propellant at a concentration of about 3% to about 35% by weight of the foamable emulsion composition;
- wherein, the liquid wax comprises at least one fatty alcohol at a concentration of more than 12% or about 12% by weight of the carrier;
- wherein presence of the liquid wax enables the solid wax to solubilize;
- wherein the composition is substantially free from crystals and is sufficiently flowable;
- wherein the carrier being otherwise free of polymeric agent;
- and
- wherein, upon release from a pressurized container, a breakable foam is produced.
11 more elements
A foamable emulsion composition comprising:
- A. a carrier comprising:
- a. a liquid wax comprising at least one fatty acid or at least one fatty alcohol;
- b. a stabilizer component comprising a non ionic surface-active agent;
- c. water;
- and
- d. more than 7% by weight of the carrier of a solid wax selected from the group consisting of a fatty acid, a fatty alcohol, a microcrystalline wax, a paraffin wax, a petroleum wax, a polyethylene wax, beeswax, candelilla wax, castor wax, Chinese wax, Fischer-Tropsch wax, rice bran wax, tallow, wool wax and mixtures thereof;
- and
- B. a liquefied hydrocarbon gas propellant at a concentration of about 3% to about 35% by weight of the foamable emulsion composition;
- wherein, the liquid wax comprises at least one fatty acid at a concentration of more than 35% or about 35% by weight of the carrier;
- wherein presence of the liquid wax enables the solid wax to solubilize;
- wherein the composition is substantially free from crystals and is sufficiently flowable;
- wherein the carrier being otherwise free of polymeric agent;
- and
- wherein upon release from a pressurized container, a breakable foam is produced.
11 more elements
A foamable emulsion composition comprising:
- A. a carrier comprising:
- a. a liquid wax comprising at least one fatty acid or at least one fatty alcohol;
- b. a stabilizer component comprising a non ionic surface-active agent;
- c. water;
- and
- d. more than 8% or about 8% by weight of the carrier of a solid wax selected from the group consisting of a fatty acid, a fatty alcohol, a microcrystalline wax, a paraffin wax, a petroleum wax, a polyethylene wax, beeswax, candelilla wax, castor wax, Chinese wax, Fischer-Tropsch wax, rice bran wax, tallow, wool wax and mixtures thereof;
- and
- B. a liquefied hydrocarbon gas propellant at a concentration of about 3% to about 35% by weight of the foamable emulsion composition;
- wherein when the liquid wax comprises at least one fatty acid, the fatty acid is present in the composition at a concentration of more than 35% or about 35% by weight of the carrier;
- wherein when the liquid wax comprises at least one fatty alcohol, the fatty alcohol is present in the composition at a concentration of more than 12% or about 12% by weight of the carrier;
- wherein the presence of liquid wax enables the solid wax to solubilize;
- wherein the composition is substantially free from crystals and is sufficiently flowable;
- wherein the carrier being otherwise free of polymeric agent;
- and
- wherein upon release from a pressurized container, a breakable foam is produced.
12 more elements
A foamable emulsion composition comprising:
- A. a carrier comprising:
- a. a liquid wax comprising at least one fatty acid or at least one fatty alcohol;
- b. a stabilizer component comprising a non ionic surface-active agent;
- c. water;
- and
- d. more than 8% or about 8% by weight of the carrier of a solid wax selected from the group consisting of a fatty acid, a fatty alcohol, a microcrystalline wax, a paraffin wax, a petroleum wax, a polyethylene wax, beeswax, candelilla wax, castor wax, Chinese wax, Fischer-Tropsch wax, rice bran wax, tallow, wool wax and mixtures thereof;
- and
- B. a liquefied hydrocarbon gas propellant at a concentration of about 3% to about 35% by weight of the foamable emulsion composition;
- wherein when the liquid wax comprises at least one fatty alcohol, the fatty alcohol is present in the composition at a concentration of more than 12% or about 12% by weight of the carrier;
- wherein presence of the liquid wax enables the solid wax to solubilize;
- wherein the composition is substantially free from crystals and is sufficiently flowable;
- wherein the carrier being otherwise free of polymeric agent;
- and
- wherein upon release from a pressurized container, a breakable foam is produced.
11 more elements
A foamable emulsion composition comprising:
- A. a carrier comprising:
- a. a liquid wax comprising at least one fatty acid or at least one fatty alcohol;
- b. a stabilizer component comprising a non ionic surface-active agent;
- c. water;
- and
- d. more than 8% or about 8% by weight of the carrier of a solid wax selected from the group consisting of a fatty acid, a fatty alcohol, a microcrystalline wax, a paraffin wax, a petroleum wax, a polyethylene wax, beeswax, candelilla wax, castor wax, Chinese wax, Fischer-Tropsch wax, rice bran wax, tallow, wool wax and mixtures thereof;
- and
- B. a liquefied hydrocarbon gas propellant at a concentration of about 3% to about 35% by weight of the foamable emulsion composition;
- wherein when the liquid wax comprises at least one fatty acid, the fatty acid is present in the composition at a concentration of more than 35% or about 35% by weight of the carrier;
- wherein presence of the liquid wax enables the solid wax to solubilize;
- wherein the composition is substantially free from crystals and is sufficiently flowable;
- wherein the carrier being otherwise free of polymeric agent;
- and
- wherein upon release from a pressurized container, a breakable foam is produced.
11 more elements
Dependencies are inferred from the claim text.