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US 8,633,305 B2Granted
Compositions of, and methods for, alpha-1 anti trypsin Fc fusion molecules
OwnerLeland Shapiroinventor
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Abstract
A novel method of treating and preventing bacterial diseases is provided. In particular, the present invention relates to compositions and methods for inhibition of Gram negative, Gram positive and acid fast bacilli in general and tuberculosis (TB), mycobacterium avium complex (MAC), and anthrax in particular. Thus, the invention relates to modulation of cellular activities, including macrophage activity, and the like. More particularly, the present invention relates to the inhibitory compounds comprising naturally occurring and man-made inhibitors of serine.
Claims12
A construct comprising a nucleic acid sequence encoding a fusion polypeptide comprising:
- a first nucleic acid encoding mammalian alpha-1 antitrypsin (AAT);
- and
- a second nucleic acid encoding an IgG1 Fc.
Dependencies are inferred from the claim text.