Modulation of chemosensory receptors and ligands associated therewith

A compound having structural Formula (IIIb1):

• or a salt or solvate thereof;
• wherein,
• A is hydrogen, —CN, —OR9, —NO2, —S(O)cR9, —NOR9, —NHOR9, —NR9COR10, —NR9R10, —CONR9R10, —CO2R9 or —NR9CO2R10;
• R17 is hydrogen, alkyl, substituted alkyl, arylalkyl, or substituted arylalkyl;
• X1 is —CH2—, —O—, —NR9—, —S—, —S(O)—, or —S(O)2—;
• X2 is alkylene, substituted alkylene, heteroalkylene, or substituted heteroalkylene;
• m is 0 or 1;
• Y1 is heteroaryl, substituted heteroaryl, cycloheteroalkyl, substituted cycloheteroalkyl, or
• X3 and X5 are independently a covalent bond, —O— or —NR9—;
• X4 is O, NR9, N—OR9, or S;
• Rx is halo, —NO2, —CN, —OH, —NH2, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroalkyl, substituted heteroalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl or substituted heteroarylalkyl;
• n is 0, 1, 2, or 3;
• Ry is hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroalkyl, substituted heteroalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl or substituted heteroarylalkyl, —NR9R10;
• and
• each R9 and R10 is independently hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroalkyl, substituted heteroalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl or substituted heteroarylalkyl;
• with the proviso that when X1 is —O— or —S—, and m is zero;
• then X3 is not —O—.

A process of preparing a compound having structural Formula (e):

• comprising reacting a compound having structural Formula (f)
• with a base,
• wherein:
• A is —NH2 or —ORb;
• R17 is hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, or substituted arylalkyl;
• R35, R36, R37, and R38 are each independently hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, acyl, substituted acyl, halo, heteroalkyl, substituted heteroalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl or substituted heteroarylalkyl, —CN, —NO2, —OR41, —S(O)kR41, —NR41R42, —CONR41R42, —CO2R41, —SO2NR41R42, and —NR41SO2R42;
• or alternatively, R35 and R36, R36 and R37, or R37 and R38, together with the atoms to which they are bonded, form a cycloalkyl, substituted cycloalkyl, heterocycloalkyl, or substituted heterocycloalkyl ring;
• Ra is —CN, —C(O)Rb, —C(O)ORb, —C(O)N(Rb)2;
• each Rb is independently hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, acyl, substituted acyl, heteroalkyl, substituted heteroalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, or substituted heteroarylalkyl;
• and
• R41 and R42 are independently hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, acyl, substituted acyl, heteroalkyl, substituted heteroalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl or substituted heteroarylalkyl;
• or alternatively R41 and R42, together with the atoms to which they are bonded, form a cycloheteroalkyl or substituted cycloheteroalkyl ring.