Indanyloxyphenylcyclopropanecarboxylic acids

A compound of formula (I)

• wherein:
• R1 is selected from the group R1-G1 consisting of a phenyl ring, a tetrazolyl ring,
• a 5-membered heteroaromatic ring containing 1 —NH—, or —S— group,
• a 5-membered heteroaromatic ring containing 1 —NH—, or —S— group and additionally 1 or 2 ═N— atoms,
• a 6-membered heteroaromatic ring containing 1, 2 or 3 ═N— atoms,
• wherein:
• optionally a second ring is annulated to the phenyl ring or to the 5- or 6-membered heteroaromatic rings and the second ring is 5- or 6-membered, unsaturated or aromatic and may contain 1, 2, or 3 heteroatoms independently selected from ═N—, —NH—, and —S— with the proviso that only up to two of the heteroatoms are O and S and no O—O, S—S, and S—O bond is formed, and wherein in the second ring independently of the presence of heteroatoms 1 or 2 CH2 groups are optionally replaced by —C(O)—, —S(O)—, or —S(O)2—,
• the phenyl ring, tetrazolyl ring, 5- or 6-membered heteroaromatic ring, annulated phenyl ring, and annulated 5- or 6-membered heteroaromatic ring are optionally substituted at a carbon atom with one group R1a,
• the phenyl ring, tetrazolyl ring, 5- or 6-membered heteroaromatic ring, annulated phenyl ring, and annulated 5- or 6-membered heteroaromatic ring are optionally additionally substituted at carbon atoms with 1 to 3 groups independently selected from R1b, and
• wherein the H-atom in one or more NH groups present in the tetrazolyl ring, 5- or 6-membered heteroaromatic ring, annulated phenyl ring, or annulated 5- or 6-membered heteroaromatic ring optionally is replaced by RM,
• H, F, Cl, Br, I, NC—, C1-8-alkyl, C2-6-alkenyl, C2-6-alkynyl, C3-8-cycloalkyl, C3-8 cycloalkyl C1-4-alkyl, C5-12-bicycloalkyl-, C5-6-cycloalkenyl, C5-6-cyclo C1-8-alkyloxy, C3-6-cycloalkyl-oxy, C3-6-cycloalkyl-C1-4-alkyloxy, —NHRN, HNRM—C(O)—, C1-4-alkyl-NRM—C(O)—, wherein any of the saturated and unsaturated aliphatic and carbocyclic groups and submoieties within the groups mentioned are optionally independently substituted with one or more F atoms and/or 1 to 3 R1c groups,
• R2 is selected from the group R2-G1 consisting of F, Cl, Br, I, C1-4-alkyl, C3-6-cycloalkyl, NC—, H2N—C(O)—, C1-4-alkyl-NRM—C(O)—, HO—C(O)—, C1-4-alkyl-O—C(O)—, C1-4-alkyloxy, and C1-4-alkyl-S(O)2—, wherein any alkyl and cycloalkyl group or sub-group within the groups mentioned is optionally substituted with one or more F atoms, and wherein multiple R2 are identical or different, if m is 2 or 3;
• R3 is selected from the group R3-G1 consisting of F, Cl, Br, I, NC—, C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl, C3-6-cycloalkyl-, C1-4-akyl-NH—, (C1-4-alkyl)2N—, C1-6-alkyl-O—, C3-6-cycloalkyl-O—, C1-4-alkyl-S—, C1-4-alkyl-S(O)—, and C1-4-alkyl-S(O)2, wherein each alkyl and cycloalkyl group and each alkyl and cycloalkyl sub-group within the groups mentioned is optionally substituted with 1 or more F atoms;
• m is 0, 1, 2, and or 3;
• n is 0, 1, 2, and or 3;
• R1a is selected from the group R1a-G1 consisting of
• C1-6 alkyl, C2-6-alkenyl, C2-6-alkynyl, C3-6-cycloalkyl-, C3-6-cycloalkyl-C1-6-alkyl, C1-4-alkyl-NH—, (C1-4-alkyl)2N—, —NHRN, HNRM—C(O)—, C1-4-alkyl-NRM—C(O)—, C1-6-alky-O—, C3-6-cycloalkyl-O—, C3-6-cycloalkyl-C1-6-alkyl-O—, C1-4-alkyl-S—, C1-4-alkyl-S(O)—, and C1-4-alkyl-S(O)2,
• wherein:
• a —CH2— member within a C4-6-cycloalkyl- group or sub-group within the groups mentioned optionally is replaced by —NRN—, —O—, —S—, —S(O)—, or —S(O2)—, or
• a >CH—CH2— member or a —CH2—CH2— member within a C5-6-cycloalkyl- group or sub-group within the groups mentioned optionally is replaced by >N—C(O)—, >N—S(O)—, >N—S(O)2—, —N(RM)—C(O)—, —N(RM)—S(O)—, or —N(RM)—S(O)2—, and
• each alkyl and cycloalkyl group and each alkyl and cycloalkyl sub-group within the groups mentioned optionally is substituted with HO—, HO—C1-4-alkyl-, C1-4-alkyl-oxy, C1-4-alkyl-oxy-C1-4-alkyl-, C1-4-alkyl-sulfanyl, C1-4-alkyl-sulfinyl, C1-4-alkyl-sulfonyl, H2N—C(O)—, C1-4-alkyl-NH—C(O)—, (C1-4-alkyl)2N—C(O)—, or C3-6-cycloalkyl-NRM—C(O)— and/or optionally substituted with 1 or more F atoms;
• a phenyl ring, a tetrazolyl ring,
• a 5-membered heteroaromatic ring containing 1 —NH—, —O—, or —S— group,
• a 5-membered heteroaromatic ring containing 1 —NH—, —O—, or —S— group and additionally 1 or 2 ═N— atoms,
• a 6-membered heteroaromatic ring containing 1, 2, or 3 ═N— atoms,
• wherein the rings are optionally substituted with one or more groups selected from R1b;
• and
• wherein the H-atom in one or more NH groups present in the tetrazolyl ring or 5-membered heteroaromatic ring is replaced by RM,
• R1b is selected from the group R1b-G1 consisting of F, Cl, Br, I, CN, —OH, C1-4-alkyl, C3-6-cycloalkyl-, HO—C1-4-alkyl, C1-4-alkyl-O—C1-4-alkyl, —NRNH, C1-4-alkyl-NRN—, C1-4-alkyl-O—, C3-6-cycloalkyl-O—, C1-4-alkyl-O—C1-4-alkyl-O—, C1-4-alkyl-S—, C1-4-alkyl-S(O)—, and C1-4-alkyl-S(O)2—, wherein any alkyl and cycloalkyl group or sub-group within the groups mentioned is optionally substituted with 1 or more F atoms;
• R1c is selected from the group R1c-G1 consisting of F, Cl, Br, I, CN, —OH, C1-3-alkyl, HO—C1-3-alkyl, C1-4-alkyl-O—, and C1-3-alkyl-O—C1-3-alkyl, wherein any alkyl group or sub-group within the groups mentioned is optionally substituted with 1 or more F atoms;
• and
• RN is independently selected from the group RN-G1 consisting of H, C1-4-alkyl, HO—C2-4-alkyl (with the proviso that at least 2 carbon atoms are between the HO-group and an NH), C1-4-alkyl-O—C2-4-alkyl- (with the proviso that at least 2 carbon atoms are between an O-group and an NH), C1-4-alkyl-C(O)—, C1-4-alkyl-O—C(O)—, and C1-4-alkyl-S(O)2, wherein any alkyl group or sub-group within the groups mentioned is optionally substituted with 1 or more F atoms;
• RM is independently selected from the group RM-G1 consisting of H, C1-4 alkyl, HO—C2-4-alkyl (with the proviso that at least 2 carbon atoms are between the HO-group and an NH), and C1-4-alkyl-O—C2-4-alkyl- (with the proviso that at least 2 carbon atoms are between an O-group and an NH), wherein any alkyl group or sub-group within the groups mentioned is optionally substituted with 1 or more F atoms;
• wherein in any definition mentioned hereinbefore and if not specified otherwise, any alkyl group or sub-group may be straight-chained or branched, or a salt thereof.