Process for nanoemulsification of curcumin and derivatives of curcumin
AssigneeLaila Pharmaceutical Pvt., Ltd.
InventorsAnitha Krishnan Nair, Ramchand Nanappan Chaniyilparampu, Kiran Bhupathiraju, Rama Raju Gokaraju, Ganga Raju Gokaraju, Trimurtulu Golakoti
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Abstract
A process for nanomulsification of highly lipophillic polyphenols compounds using non-ionic surfactant and a non-ionic co-solvent with the help of sonar energy, to enhance the aqueous solubility is disclosed herein.
Claims20
A process for enhancing the aqueous solubility of a curcuminoid, comprising:
- a. sonicating said curcuminoid in a medium comprising a non-ionic surfactant and a non-ionic co-solvent, wherein said co-solvent is polyethylene glycol;
- wherein said sonicating produces nanoparticles of said curcuminoid having a log-normal particle size distribution with a peak particle size of between 1 nm and 50 nm.
A process for enhancing the aqueous solubility of curcuminoids, comprising:
- a. nanoemulsifying said curcuminoids in a medium comprising a non-ionic surfactant and a non-ionic co-solvent with sonication, wherein said co-solvent comprises polyethylene glycol;
- wherein said nanoemulsifying produces nanoparticles of said curcuminoids having a log-normal particle size distribution with a peak particle size of between 2 nm and 20 nm.
A process to enhance the aqueous solubility of a curcuminoid, wherein said process comprises:
- a. stirring a mixture of the curcuminoid and a non-ionic surfactant to produce a mixture;
- b. adding polyethylene glycol to the mixture with continued stirring in order to disperse the curcuminoid in the mixture;
- c. subjecting the mixture to sonication to produce nanoparticles of the curcuminoid having a log-normal particle size distribution with a peak particle size of between 1 and 50 nm;
- and
- d. subsequent to subjecting the mixture to sonication, dispersing the mixture into an aqueous phase followed by stirring to solubilize the curcuminoids in water.
A process for enhancing the aqueous solubility of curcuminoids, comprising:
- nanoemulsifying said curcuminoids in a medium comprising a non-ionic surfactant and a non-ionic co-solvent with sonication to produce particles of said curcuminoids having a defined average particle size;
- wherein said defined average particle size is in the range of 8-11 nm.
A process for enhancing the aqueous solubility of curcuminoids, comprising:
- sonicating said curcuminoids in a medium comprising a non-ionic surfactant and a non-ionic co-solvent to produce a sonicated mixture containing nanoparticles of said curcuminoids;
- wherein said nanoparticles of said curcuminoids have a log-normal particle size distribution with a peak particle size of between 2 nm and 20 nm.
Dependencies are inferred from the claim text.