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US 8,629,263 B2Granted
Nucleoside phosphoramidates
AssigneeGilead Pharmasset LLC
InventorsBruce Ross, Michael Joseph Sofia, Ganapati Reddy Pamulapati, Suguna Rachakonda, Hai-Ren Zhang, Byoung-Kwon Chun, Peiyuan Wang
Life of this patent
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Abstract
Disclosed herein are nucleoside phosphoramidates and their use as agents for treating viral diseases. These compounds are inhibitors of RNA-dependent 5 RNA viral replication and are useful as inhibitors of HCV NS5B polymerase, as inhibitors of HCV replication and for treatment of hepatitis C infection in mammals.
Claims25
A compound represented by the structure:
- wherein LG′ is tosylate, camphorsulfonate, an aryloxide, or an aryloxide substituted with at least one electron withdrawing group.
A compound represented by the structure:
- wherein LG′ is a leaving group.
A compound represented by the following structure:
A compound represented by the following structure:
Dependencies are inferred from the claim text.