Modulators of ATP-binding cassette transporters
AssigneeVertex Pharmaceuticals Incorporated
InventorsSara Hadida-Ruah, Anna Hazlewood, Peter D. J. Grootenhuis, Fredrick Van Goor, Ashvani Singh, Jinglan Zhou, Jason McCartney
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Abstract
The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
Claims6
A method of treating or lessening the severity of a moderate to mild clinical phenotype of cystic fibrosis in a patient, said method comprising the step of administering to said patient a pharmaceutical composition comprising N-(5-hydroxy-2,4-ditert-butyl-phenyl)-4-oxo-1H-quinoline-3-carboxamide.
Dependencies are inferred from the claim text.