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US 8,628,937 B2Granted
Vaccines with enhanced immune response and methods for their preparation
AssigneeImmunovaccine Technologies Inc.
InventorsRobert George Brown, Bill Pohajdak, Warwick Charles Kimmins
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Abstract
The present invention is concerned with vaccines and their preparation. An effective long-term immune response, especially in mammals, can be produced using a vaccine comprising an antigen encapsulated in liposomes, a suitable adjuvant and a carrier comprising a continuous phase of a hydrophobic substance. The vaccine is particularly effective in eliciting the production of antibodies that recognize epitopes of native proteins.
Claims19
A method of preparing a vaccine composition comprising an antigen, an adjuvant, liposomes, and a carrier, the method comprising:
- (a) providing an antigen, an adjuvant, and liposomes, the liposomes comprising a phospholipid with at least one head group selected from the group consisting of phosphoglycerol, phosphoethanolamine, phosphoserine, phosphocholine and phosphoinositol;
- and
- (b) mixing the antigen, the adjuvant and the liposomes with a carrier comprising a continuous phase of mineral oil, whereby the liposomes are suspended in the carrier;
- whereby the vaccine composition is produced.
1 more element
Dependencies are inferred from the claim text.