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US 8,624,063 B2Granted
Non-lactone carbocyclic and heterocyclic antagonists and agonists of bacterial quorum sensing
AssigneeWisconsin Alumni Research Foundation
InventorsHelen E. Blackwell, Christine E. McInnis
Life of this patent
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Abstract
Compounds which modulate quorum sensing in quorum sensing bacteria. Compounds of the invention inhibit quorum sensing and/or activate quorum sensing in various bacteria. Compounds that inhibit quorum sensing are particularly useful for inhibition of detrimental bacterial biofilm formation. Compounds that activate quorum sensing are particularly useful for promoting growth and biofilm formation of beneficial bacterial.
Claims11
A compound of formula:
- A—CO—CH2—CO—NH—[CH2]p2-HG
- or a pharmaceutically acceptable salt or ester thereof
- where:
- p2 is 1 or 2;
- A is an unsubstituted alkyl or alkenyl group having 4-10 carbon atoms;
- and
- HG is a phenyl group substituted with one or more substituents selected from the group consisting of halogen, nitro, hydroxyl, nitrile, azide, —R, or —OR wherein R is an alkyl group having 1-6 carbon atoms.
4 more elements
A compound represented by formula:
- or a pharmaceutically acceptable salt or ester thereof
- wherein HG is a phenyl group optional substituted with one or more non-hydrogen substituents selected from the group consisting of halogen, nitro, azide, alkyl having 1-3 carbon atoms, haloalkyl having 1-3 carbon atoms, alkoxy having 1-3 carbon atoms, and p2 is 1 or 2.
Dependencies are inferred from the claim text.