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US 8,623,897 B2Granted
Methods and compositions for treatment of diabetes and dyslipidemia
AssigneeKareus Therapeutics, SA
InventorsIsh Khanna, Sivaram Pillarisetti
Life of this patent
Estimating the term…
Abstract
The invention is directed to novel compounds of Formula I: as well as its stereoisomers and/or pharmaceutically acceptable salts, for the treatment of diabetes and diabetes associated dyslipidemia.
Claims12
A composition comprising at least one compound according to Formula I:
- its stereoisomers and/or pharmaceutically acceptable salts, wherein:
- R1 is selected from a group consisting of hydroxy, alkoxy, amine, alkyl, haloalkyl, NHSO2R, or NHCOR wherein R is selected from alkyl or cycloalkyl, NHR′ wherein R′ is alkyl or cycloalkyl optionally substituted by hydroxy or alkoxy;
- n1 and n2 are independently selected from 0, 1, and 2;
- at least one of R3 and R4 and/or R5 and R6 form a cyclic ring of 3-8 carbon atoms optionally containing alkyl groups, hetero atoms, or functional groups such as O, N, SO2;
- R3 and R4 or R5 and R6, when they do not form a cyclic ring, are independently selected from hydrogen, alkyl, branched alkyl, and cycloalkyl;
- L1 is a linear aliphatic chain optionally containing from 4 to 16 carbon atoms, optionally substituted one or more times by alkyl, branched alkyl, cycloalkyl, or aryl;
- R2 is independently selected from hydrogen, alkoxy, hydroxy, alkyl, haloalkyl, cycloalkyl, heterocycloalkyl, heteroaryl, cyano, or COR7, wherein R7 is selected from hydroxy, alkyl, alkoxy, or amine, NHR′, NHSO2R, or NHCOR;
- Y1 is oxygen or hydrogen;
- Y2 is optional, and wherein when Y2 is present, Y1 and Y2 are hydrogen and when Y2 is not present, Y1 forms a carbonyl group.
6 more elements
A method for the treatment of insulin resistance, diabetes, and/or cardiovascular disease in a subject, the method comprising administering to the subject at least one compound according to Formula I:
- its stereoisomers and/or pharmaceutically acceptable salts, wherein:
- R1 is selected from a group consisting of hydroxy, alkoxy, amine, alkyl, haloalkyl, NHSO2R, or NHCOR wherein R is selected from alkyl or cycloalkyl, NHR′ wherein R′ is alkyl or cycloalkyl optionally substituted by hydroxy or alkoxy;
- n1 and n2 are independently selected from 0, 1, and 2;
- at least one of R3 and R4 and/or R5 and R6 form a cyclic ring of 3-8 carbon atoms optionally containing alkyl groups, hetero atoms, or functional groups such as O, N, SO2;
- R3 and R4 or R5 and R6, when they do not form a cyclic ring, are independently selected from hydrogen, alkyl, branched alkyl, and cycloalkyl;
- L1 is a linear aliphatic chain optionally containing from 4 to 16 carbon atoms, optionally substituted one or more times by alkyl, branched alkyl, cycloalkyl, or aryl;
- R2 is independently selected from hydrogen, alkoxy, hydroxy, alkyl, haloalkyl, cycloalkyl, heterocycloalkyl, heteroaryl, cyano, or COR7, wherein R7 is selected from hydroxy, alkyl, alkoxy, or amine, NHR′, NHSO2R, or NHCOR;
- Y1 is oxygen or hydrogen;
- Y2 is optional, and wherein when Y2 is present, Y1 and Y2 are hydrogen and when Y2 is not present, Y1 is a carbonyl group.
6 more elements
Dependencies are inferred from the claim text.