Human recombinant monoclonal antibody that specifically binds to VCAM-1 and inhibits adhesion and transmigration between leukocytes and endothelial cells

A human recombinant monoclonal antibody, which specifically binds to human Vascular Cell Adhesion Molecule-1 (VCAM-1) to inhibit adhesion between leukocytes and activated endothelial cells and transmigration of leukocytes through the activated endothelial cells, wherein the human recombinant monoclonal antibody comprises:

• (a) a heavy chain variable region that contains heavy chain CDR1 as defined by SEQ ID NO.2;
• heavy chain CDR2 as defined by SEQ ID NO.3;
• and heavy chain CDR3 as defined by SEQ ID NO.4, and a light chain variable region that contains light chain CDR1 as defined by SEQ ID NO. 6;
• light chain CDR2 as defined by SEQ ID NO.7;
• and light chain CDR3 as defined by SEQ ID NO.8;
• or
• (b) a heavy chain variable region that contains heavy chain CDR1 as defined by SEQ ID NO. 10;
• heavy chain CDR2 as defined by SEQ ID NO. 11;
• and heavy chain CDR3 as defined by SEQ ID NO. 12, and a light chain variable region that contains light chain CDR1 as defined by SEQ ID NO. 14;
• light chain CDR2 as defined by SEQ ID NO. 15;
• and light chain CDR3 as defined by SEQ ID NO. 16.