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US 8,623,326 B2Granted
Ghrelin analogues
AssigneeThe University of Western Ontario
InventorsLeonard G. Luyt, Dina Rosita
Life of this patent
Estimating the term…
Abstract
Ghrelin analogues having high affinity for a target receptor in diseased cells are provided, as well as methods of diagnosis and treatment utilizing such analogues.
Claims7
A ghrelin analogue comprising a peptide comprising a sequence ranging from at least amino acid residues 1-7 of SEQ ID NO:
- 1 to a sequence of up to amino acid residues 1-28 of SEQ ID NO:
- 1 and an imaging agent, wherein said imaging agent is attached to the peptide at the amino acid residue at position 3 of SEQ ID NO:
- 1 via a linker which consists of an amide linkage and 4 to 12 methylene or an aromatic entity selected from the group consisting of phenyl, biphenyl, naphthyl and cyclopentyldienyl, and wherein the imaging agent and linker replace the n-octanoyl group of SEQ ID NO:
- 1 and the ghrelin analogue retains receptor-binding activity.
1 more element
Dependencies are inferred from the claim text.