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US 8,618,505 B2Granted
Plasmonic electricity
AssigneeUniversity of Maryland, Baltimore County
InventorChris D. Geddes
Life of this patent
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Abstract
The present invention relates to detection systems and methods that detect fluorescence, luminescence, chemiluminescence or phosphorescence signatures in the form of an electrical signal conducted and emitted from metallic containing surfaces. Thus, the present invention provides for detecting fluorescence digitally and directly without the need for expensive detectors.
Claims19
A system for generating electrical current, the system comprising:
- a substrate comprising a metallic material positioned on the substrate, wherein the metallic material is shaped as particles, nanostructures, island or colloids;
- a set of electrically conductive electrodes communicatively contacting at least two of the metallic particles positioned thereon;
- an electricity storage device or a current reading device communicatively connected to at least one electrode;
- an electromagnetic energy source;
- an intrinsic or extrinsic fluorophore positioned near the metallic material, wherein excitation of the fluorophore by electromagnetic energy induces a mirror dipole in the metallic material causing plasmonic current flow for storage in the storage device or directing to the current reading device.
2 more elements
An assay detection method comprising:
- providing a conductive metallic material on a substrate;
- wherein the conductive metallic material is shaped as a non-continuous film, particles, nanostructures, island or colloids and wherein the substrate has a first end and an opposing second end;
- communicatively contacting the first and second end of the substrate and at least some of the metallic particles positioned thereon to a first and second electrode, wherein the first and second electrodes are communicatively connected to a current reading device;
- introducing at least one biomolecule for disposing near the conductive metallic material, wherein the biomolecule is capable of inducing a mirror dipole in the metallic material and such dipole is enhanced by a predetermined proximity to the metallic material;
- applying electromagnetic energy from an electromagnetic energy source to excite the biomolecule and inducing a mirror dipole in the metallic material causing plasmonic current flow, and
- measuring the plasmonic current flow by the current flow detector.
3 more elements
A method of metal-enhanced fluorescence sensing, comprising:
- applying a conductive metallic material to a surface used in a detection system, wherein the surface includes glass, quartz, or a polymeric material, wherein the surface has a first and second end, wherein the first and second end and at least some of the metallic material is communicatively connected to a first and second electrodes with a current measuring device positioned therebetween;
- introducing a polar solution containing at least one biomolecule for disposing near the conductive metallic surface, wherein the biomolecule is capable of excitation causing either a dipole moment or fluorescing;
- exciting the biomolecule with an electromagnetic source to cause the dipole moment or fluorescing and whereby such excitement induces a dipole in the metallic material causing plasmonic current flow;
- measuring the plasmonic current flow with the current reading device.
1 more element
An assay method comprising:
- providing at least one vessel or container;
- wherein a first and second electrode are positioned within the vessel or communicatively connected thereto;
- introducing metallic nanostructures into the vessel, wherein the vessel includes a polar solution, wherein the metallic nanostructures can be free in solution or connected to a surface of the vessel;
- introducing a molecule that exhibits dipole activity upon excitation and disposing such molecule near the metallic nanostructures, wherein the metallic nanostructure is positioned a predetermined proximity to the metallic nanostructures to induce a mirror dipole in the metallic nanostructures;
- and
- measuring the current flow.
3 more elements
Dependencies are inferred from the claim text.