Back to results
US 8,618,477 B2Granted
Method and apparatus for chemical and biological sample separation
AssigneeExcellims Corporation
InventorsClinton Alawn Krueger, Ching Wu
Life of this patent
Estimating the term…
Abstract
The present invention involves a series of shifting reagents that selectively interact with a targeted functional group of biological molecules, pharmaceutical drugs, small molecules, chemicals, chemical agents, or explosives resulting in a structure selective based drift time shift in the IMS. Additional energy is used to enhance the mobility based separation; in particular, the energy level can be tuned.
Claims17
A ion mobility based separation method, comprising:
- a. adding a shifting reagent with one or more chiral centers to a sample, which interacts with at least one component of the sample;
- b. separating at least one component of the sample in a drift media based on their measured ion mobility characteristics;
- and
- c. providing energy in addition to the thermal energy at a given temperature to one or more of:
- the components and/or the shifting reagent and/or the drift media influencing the separation of the components in the sample.
2 more elements
A ion mobility based spectrometer, comprising:
- a. a chiral shifting reagent added to a sample;
- b. a drift media wherein at least one component of the sample is separated based on their ion mobility characteristics;
- and
- c. one of more energy sources that provide energy in addition to the thermal energy at a given temperature to one or more of:
- the sample, and/or the shifting agent, and/or the drift media influencing the separation of the components in the sample.
2 more elements
Dependencies are inferred from the claim text.