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US 8,618,470 B2Granted
Laser based identification of molecular characteristics
AssigneeBoard of Trustees of Michigan State University
InventorsMarcos Dantus, Vadim V. Lozovoy
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Abstract
Enantiomers are characterized, identified, synthesized and/or modified with a shaped laser pulse. In another aspect of the present invention, binary shaping and circular polarization are employed with a laser pulse. A further aspect of the present invention provides a quarter-wave plate in combination with one or more pulse shapers.
Claims27
A method of manufacturing a pharmaceutical compound, the method comprising:
- (a) emitting a laser beam;
- (b) shaping the laser beam with a shaper;
- (c) polarizing the laser beam;
- (d) testing the pharmaceutical compound with the shaped and polarized laser beam;
- (e) automatically determining a chiral property of the pharmaceutical compound based on the test;
- (f) creating a substantially helical and propeller-like direction and curvature of the polarized and shaped laser beam to cause enantiomeric selectivity;
- and
- (g) detecting a characteristic of the pharmaceutical compound with an ion trap mass spectrometer while interrogating ions in the pharmaceutical compound with phase and polarization shaped laser beam pulses.
5 more elements
A method of manufacturing a pharmaceutical product, the method comprising:
- (a) emitting a set of laser beam pulses on the pharmaceutical product, each of the pulses having a duration of less than 100 femtoseconds;
- (b) shaping the pulses with a shaper to control phase and amplitude in the pulses;
- (c) automatically detecting and compensating for distortions in the pulses, without a genetic learning algorithm;
- (d) polarizing the pulses after step (b) to control the electric field direction therein;
- (e) detecting or changing a characteristic of the pharmaceutical product with the shaped and polarized pulses;
- and
- (f) detecting a characteristic of the pharmaceutical product with an ion trap mass spectrometer while interrogating ions in the pharmaceutical product with phase and polarization shaped laser beam pulses.
4 more elements
A method of operating a laser system, the method comprising:
- (a) emitting a laser beam pulse on a pharmaceutical compound;
- (b) minimizing phase distortions of the pulse by pulse shaping without a genetic learning algorithm;
- (c) polarization shaping of the pulse after step (b);
- and
- (d) detecting a characteristic of a pharmaceutical compound with an ion trap mass spectrometer while interrogating ions in the pharmaceutical compound with phase and polarization shaped laser beam pulses.
2 more elements
Dependencies are inferred from the claim text.