Transgenic porcine models of cystic fibrosis
AssigneesUniversity of Iowa Research Foundation, The Curators of the University of Missouri
InventorsMichael J. Welsh, Christopher S. Rogers, Randall Prather, John Engelhardt, Ziying Yan
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Abstract
The present invention provides transgenic, large non-human animal models of diseases and conditions, as well as methods of making and using such animal models in the identification and characterization of therapies for the diseases and conditions.
Claims11
A transgenic pig whose genome comprises a homozygous disruption of a cystic fibrosis membrane transporter (CFTR) gene, wherein the pig does not express functional CFTR, and wherein the pig has a symptom of cystic fibrosis in its pancreas, intestine, liver, or gallbladder.
Dependencies are inferred from the claim text.