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US 8,618,308 B2Granted
Process for the preparation of 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylates
AssigneeShanghai Institute of Pharmaceutical Industry
InventorsFuli Zhang, Taizhi Wu, Meihua Xie
Life of this patent
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Abstract
The present invention discloses a process for obtaining 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate by the reaction of 4,4-dimethyl-2-propyl-4,6-dihydrofuro[3,4-d]imidazole, or its hydrolysis product, or its ring-opening product, with alcohol under appropriate catalytic conditions. Furthermore, the present invention also provides a process for obtaining high purity 4,4-dimethyl-2-propyl-4,6-dihydrofuro[3,4-d]imidazole.
Claims12
A process for the preparation of compound of formula I,
- comprising mixing compound of formula II or formula III, with alcohol R—OH and a catalyst for transesterification or a condensation agent for oxygen acylation to produce compound of formula I,
- wherein R is selected from C1-C6 alkyl.
Dependencies are inferred from the claim text.