Compounds that modulate intracellular calcium

A compound of Formula (I):

• wherein:
• A is C3-C8cycloalkyl, C2-C8heterocycloalkyl, aryl or heteroaryl wherein C3-C8cycloalkyl, C3-C8heterocycloalkyl, aryl or heteroaryl are independently optionally substituted with at least one R;
• or A is aryl or heteroaryl substituted with two R groups on adjacent carbon atoms wherein the two R groups and the carbon atoms to which they are attached form a C4-C8cycloalkyl or C2-C8heterocycloalkyl;
• R is selected from F, Cl, Br, I, —CN, —NO2, —CF3, —OH, —OR3, —OCF3, —C═CH, —C═CR3, C1-C6alkylenealkyne, C1-C6alkyl, C3-C6cycloalkyl, C1-C6heteroalkyl, C1-C6haloalkyl, tetrazolyl, C2-C6heterocycloalkyl, phenyl, —NHS(═O)2R3, S(═O)2N(R4)2, —C(═O)CF3, —C(═O)NHS(═O)2R3, —S(═O)2NHC(═O)R4, N(R4)2, —N(R4)C(═O)R3, —CO2R4, —C(═O)R3, —OC(═O)R3, —C(═O)N(R4)2, —SR3, —S(═O)R3, and —S(═O)2R3;
• J is a bond, NHS(═O)2, S(═O)2N(R4), —C(═O), —C(═O)NHS(═O)2, —S(═O)2NHC(═O), N(R4), —N(R4)C(═O), —CO2, —C(═O), —OC(═O), —C(═O)N(R4), —S, —S(═O), and —S(═O)2, C1-C6alkylene, C2-C6alkenylene, C2-C6alkynylene, C1-C6heteroalkylene, C3-C6cycloalkylene, or C2-C6heterocycloalkylene, wherein C1-C6alkylene, C2-C6alkenylene, C2-C6alkynylene, C1-C6heteroalkylene, C3-C6cycloalkylene, and C2-C6heterocycloalkylene is optionally substituted with at least one R;
• Q is selected from hydrogen, F, Cl, Br, I, —CN, —NO2, —CF3, —OH, —OR3, —OCF3, C1-C6alkyl, C1-C6alkenyl, C1-C6alkynyl, C3-C8cycloalkyl, C3-C8cycloalkenyl, C1-C6heteroalkyl, C1-C6haloalkyl, C2-C6heterocycloalkyl, aryl, heteroaryl, —NHS(═O)2R3, S(═O)2N(R4)2, —C(═O)CF3;
• —C(═O)NHS(═O)2R3, —S(═O)2NHC(═O)R4, N(R4)2, —N(R4)C(═O)R3, —CO2R4, —C(═O)R3, —OC(═O)R3, —C(═O)N(R4)2, —SR3, —S(═O)R3, and —S(═O)2R3;
• R1 is CO2R2, wherein R2 is hydrogen, C1-C6alkyl, C1-C6cycloalkyl, C1-C6haloalkyl, phenyl or benzyl;
• Z is O, S, NH, N—CN, or CHNO2;
• X is W-L-B, or B wherein B is optionally substituted with at least one R;
• W is NR2, O or a bond;
• L is methylene, ethylene substituted with at least one R, C3-C6alkylene, C2-C6alkenylene, C6alkynylene, C1-C6heteroalkylene, C3-C6cycloalkylene, or C2-C6heterocycloalkylene, wherein methylene, C3-C6alkylene, C2-C6alkenylene, C2-C6alkynylene, C1-C6heteroalkylene, C3-C6cycloalkylene, and C2-C6heterocycloalkylene is optionally substituted with at least one R;
• B is C3-C10cycloalkyl, C2-C8heterocycloalkyl, aryl or heteroaryl;
• each R3 is independently selected from C1-C6alkyl, C1-C6haloalkyl, C3-C8cycloalkyl, phenyl, and benzyl;
• each R4 is independently selected from hydrogen, C1-C6alkyl, C1-C6haloalkyl, C3-C8cycloalkyl, phenyl, and benzyl;
• or
• a pharmaceutically acceptable salt, or N-oxide thereof.