Indolizine inhibitors of leukotriene production

A compound of formula (I):

• or pharmaceutically acceptable salts thereof, wherein:
• A is N and B is C, or A is C and B is N;
• ring D is C6-10 aryl;
• X1 is —C(O)—;
• X2 is —CH2C(C1-2alkyl)2— or
• X3 is —C(O)—, or —C(O)—N(R10)—;
• X4 is —(CH2)p or —(CH2)p—O—(CH2)q—, wherein one or more hydrogen atoms of said —(CH2)p—O—(CH2)q— can be replaced by C1-6 alkyl;
• R1 is C1-6 alkyl, C1-6 alkoxy, C1-6 alkoxy C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, 4 to 8-membered heterocyclyl, phenyl, 5 to 6-membered heteroaryl, or N(R8)2—, wherein each C1-6 alkyl, C1-6 alkoxy, C1-6 alkoxy C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, 4 to 8-membered heterocyclyl, phenyl, and 5 to 6-membered heteroaryl of said R1 substituent where possible is optionally substituted with one to four hydroxyl, halogen, or C1-6 alkyl;
• R2 is R9OC(O)—, NH(R8)—C(O)— or R9—S(O)2—NH—C(O)—;
• each R3 when present is independently hydroxyl, halogen, cyano, C1-6 alkyl, C1-6 alkoxy, C1-6 alkoxy C1-6 alkyl, C3-10 cycloalkyl, 5 to 11-membered heterocyclyl, C6-10 aryl, 5 to 11-membered heteroaryl, R9—C(O)—, R9—O—C(O)—, N(R8)2—, N(R8)2—C(O)—, R9—C(O)—N(R8)—, (N(R8)2)(R8N═)C—N(R8)—C(O)—, R9—S(O)j—, N(R8)2—S(O)j—, R9—S(O)j—N(R8)—, R9—S(O)j—N(R8)—C(O)—, N(R8)2—S(O)j—N(R8)—C(O)—, or N(R8)2—C(O)—N(R8)—S(O)j—, wherein each C1-6 alkyl, C1-6 alkoxy, C1-6 alkoxy C1-6 alkyl, C3-10 cycloalkyl, 5 to 11-membered heterocyclyl, C6-10 aryl, and 5 to 11-membered heteroaryl of said R3 substituent where possible is optionally substituted with one to four R6 groups;
• R4 is hydrogen, C1-6 alkyl, C3-10 cycloalkyl, 5 to 11-membered heterocyclyl, C6-10 aryl, or 5 to 11-membered heteroaryl, wherein each C1-6 alkyl, C3-10 cycloalkyl, 5 to 11-membered heterocyclyl, C6-10 aryl, and 5 to 11-membered heteroaryl of said R4 where possible is optionally substituted with one to four R7 groups;
• R6, and R7 are each independently halogen hydroxyl, carboxy, C1-6 alkyl, C1-6 alkoxy, C1-6 alkoxy C1-6 alkyl, R9—C(O)—, R9—O—C(O)—, N(R8)2—, N(R8)2—C(O)—, R9—C(O)—N(R8)—, R9—S(O)j—, R9—S(O)j—N(R8)—, or N(R8)2—S(O)j—;
• each R8 is independently hydrogen, C1-6 alkyl, C3-10 cycloalkyl, 5 to 11-membered heterocyclyl, C6-10 aryl, or 5 to 11-membered heteroaryl, wherein two R8 groups when attached to the same nitrogen atom can join to form a 4 to 8-membered heterocyclyl;
• each R9 is independently hydrogen, C1-6 alkyl, C3-10 cycloalkyl, 5 to 11-membered heterocyclyl, C6-10 aryl, or 5 to 11-membered heteroaryl;
• R10 is hydrogen, C1-6 alkyl, carboxy C1-6 alkyl, or C1-6 alkoxy C1-6 alkyl;
• j is 0, 1 or 2;
• m is 0, 1, 2 or 3;
• n is an integer from 1 to 6;
• and
• p and q are each independently 0, 1 or 2.