HSP90 inhibitors
AssigneeTakeda Pharmaceutical Company Limited
InventorsJohn D. Lawson, Erick Wang Co, Jeffrey A. Stafford
Life of this patent
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Abstract
The invention relates to HSP90 inhibiting compounds consisting of the formula: wherein the variables are as defined herein. The invention also relates to pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
Claims6
The compound (R,Z)-2-amino-7-(4-fluoro-2-(6-methoxypyridin-2-yl)phenyl)-4-methyl-7,8-dihydropyrido[4,3-d]pyrimidin-5(6H)-one O—(R)-2,3-dihydroxypropyl oxime or a pharmaceutically acceptable salt thereof.
The compound (R,Z)-2-amino-7-(4-fluoro-2-(6-methoxypyridin-2-yl)phenyl)-4-methyl-7,8-dihydropyrido[4,3-d]pyrimidin-5(6H)-one O—(S)-2,3-dihydroxypropyl oxime or a pharmaceutically acceptable salt thereof.
The compound (R,Z)-2-Amino-7-(3′-(cyclopropylsulfonyl)-5-fluorobiphenyl-2-yl)-4-methyl-7,8-dihydropyrido[4,3-d]pyrimidin-5(6H)-one O—(S)-2,3-dihydroxypropyl oxime or a pharmaceutically acceptable salt thereof.
The compound (E)-2-Amino-7-(4-fluoro-2-(6-methoxypyridin-2-yl)phenyl)-4-methyl-7,8-dihydroquinazolin-5(6H)-one O—(R)-2,3-dihydroxypropyl oxime or a pharmaceutically acceptable salt thereof.
The compound (E)-2-Amino-7-(4-fluoro-2-(6-methoxypyridin-2-yl)phenyl)-4-methyl-7,8-dihydroquinazolin-5(6H)-one O—(S)-2,3-dihydroxypropyl oxime or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.