Triazole derivatives

A compound of formula I

• in which
• R1 denotes OH, OCH3, OCF3, OCHF2, OBzl, OAc, p-methoxybenzyloxy, SH, S(O)mCH3, SO2NH2, Hal, CF3, or CH3,
• R2 denotes SO2Het, SO2NHAr, SO2NAA′, SO2NHA, SO2NA[CH2)oNA2,], SO2NAHet, SO2NA-benzyl, CONHA, CONAA′, CONHAr, CONHHet, CONA-benzyl, CONA[(CH2)oOA] or CONAAr,
• R3 denotes H or Br,
• R4, R5, R6 each, independently of one another, denote H, Hal, CN, NO2, A, Alk, (CH2)nAr, (CH2)nHet, COOH, COOA, COOAr, COOHet, CONH2, CONHA, CONAA′, CONHAr, CONAAr, CON(Ar)2, CONHHet, CON(Het)2, NH2, NHA, NHAr, NHHet, NAA′, NHCOA, NHCONH2, NACOA′, NHCO(CH2)nAr, NHCOHet, NHCOOA, NHCOOAr, NHCOOHet, NHCONHA, NHCONHAr, NHCONHHet, OH, OA, O(CH2)oHet, O(CH2)oNH2, O(CH2)oCN, OAr, OHet, SH, S(O)mA, S(O)mAr, S(O)mHet, SO2NH2, SO2NHA, SO2NAA′, SO2NHAr, SO2NAAr, SO2NHHet, SO2N(Ar)2, or SO2N(Het)2,
• R4 and R5, together also denote OCH2O, OCH2CH2O, —CH═CH—CH═CH—, NH—CH═CH or CH═CH—NH,
• Y denotes OH or SH,
• A, A′ each, independently of one another, denote unbranched or branched alkyl having 1-10, C atoms, in which one, two or three CH2, groups may be replaced by O, S, SO, SO2, NH, NR8, and/or by —CH═CH— groups and/or, in addition, 1-5H atoms may be replaced by F, Cl, Br and/or R7,
• Alk or cyclic alkyl having 3-7 C atoms,
• A and A′ together also denote an alkylene chain having 2, 3, 4, 5 or 6, C atoms, in which one CH2, group may be replaced by O, S, SO, SO2, NH, NR8, NCOR8 or NCOOR8,
• Alk denotes alkenyl having 2-6 C atoms,
• R7 denotes COOR9, CONR9R10, NR9R10, NHCOR9, NHCOOR9or OR9,
• R8denotes cycloalkyl having 3-7 C atoms,
• cycloalkylalkylene having 4-10 C atoms,
• Alk or
• unbranched or branched alkyl having 1-6 C atoms, in which one, two or three CH2 groups may be replaced by O, S, SO, SO2, NH and/or, in addition, 1-5 H atoms may be replaced by F and/or Cl,
• R9, R10 each, independently of one another, denote H or alkyl having 1-5 C atoms, in which 1-3 CH2, groups may be replaced by O, S, SO, SO2, NH, NMe or NEt and/or, in addition, 1-5 H atoms may be replaced by F and/or Cl,
• R9 and R10 together also denote an alkylene chain having 2, 3, 4, 5, or 6 C atoms, in which one CH2 group may be replaced by O, S, SO, SO2, NH, NR8, NCOR8, or NCOOR8,
• Ar denotes phenyl, naphthyl or biphenyl, each of which is unsubstituted or mono-, di- or trisubstituted by Hal, A, OR11, N(R11)2, NO2, CN, phenyl, CON(R11)2, NR11COA, NR11CON(R11)2, NR11SO2A, COR11, SO2N(R11)2, S(O)mA, -[C(R11)2]n—COOR11, and/or —O[C(R11)2]o—COOR11,
• Het denotes a mono- or bicyclic saturated, unsaturated or aromatic heterocycle having 1 to 4 N, O and/or S atoms, which may be mono-, di- or trisubstituted by Hal, A, OR11, N(R11)2, NO2, CN, COOR11, CON(R11)2, NR11COA, NR11SO2A, COR11, SO2NR11, S(O)mA, ═S, ═NR11, and/or ═O(carbonyl oxygen),
• R11 denotes H or A,
• Hal denotes F, Cl, Br or I,
• m denotes 0, 1, or 2,
• n denotes 0, 1, 2, 3, or 4,
• o denotes 1, 2, or 3
• or pharmaceutically usable salts, tautomers or stereoisomers thereof, including mixtures thereof in all ratios,
• where compounds selected from the group
• 5-(2,4-dihydroxyphenyl)-4-(naphth-l-yl)-4H-1,2,4-triazole-3-thiol,
• 5-(2,4-dihydroxyphenyl)-4-(2-methylphenyl)-4H-1,2,4-triazole-3-thiol,
• 5-(2,4-dihydroxyphenyl)-4-(2,5-dimethoxy)-4H-1,2,4-triazole-3-thiol,
• are excepted.