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US 8,618,278 B2Granted
RNAi-mediated inhibition of histamine receptor H1-related conditions
AssigneeAlcon Research, Ltd.
InventorsJohn M. Yanni, Jon E. Chatterton, Daniel A. Gamache, Steven T. Miller
Life of this patent
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Abstract
RNA interference is provided for inhibition of histamine receptor H1 mRNA expression, in particular, for treating patients having an HRH1-related condition or at risk of developing an HRH1-related condition such as allergic conjunctivitis, ocular inflammation, dermatitis, rhinitis, asthma, or allergy.
Claims4
A composition comprising an interfering RNA having a length of 19 to 49 nucleotides, and comprising a 19 nucleotide sequence having substantial complementarity to an mRNA corresponding to SEQ ID NO:
- 30;
- and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.