Nucleic acid encoding apoptotic anti-IgE antibodies
AssigneeGenentech, Inc.
InventorsLawren Wu, Mercedesz Balazs, Hans Brightbill, Andy Chan, Yvonne Chen, Anan Chuntharapai, Mark Dennis, Terence Wong
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Abstract
The present application relates to apoptotic anti-IgE antibodies, nucleic acid encoding the same, therapeutic compositions thereof, and their use in the treatment of IgE-mediated disorders.
Claims35
An isolated nucleic acid encoding an anti-IgE/M1′ antibody that specifically binds an epitope in the M1′ segment of IgE defined by residues 317 to 351 of SEQ ID NO:1 and which induces apoptosis in IgE-expressing B-cells.
An isolated nucleic acid encoding anti-IgE/M1′ antibody that specifically binds an epitope in the M1′ segment of IgE defined by residues 317 to 351 of SEQ ID NO:1 and which specifically depletes IgE-producing B-cells when a therapeutically effective amount is administered in vivo to a mammal.
An isolated nucleic acid encoding an anti-IgE/M1′ antibody that specifically binds to an epitope in the M1′ segment of IgE defined by the residues 317 to 351 of SEQ ID NO:1 and with a Scatchard binding affinity that is equivalent to that of the murine anti-IgE/M1′ antibody 47H4.
An isolated nucleic acid encoding an anti-IgE/M1′ antibody that specifically binds to an epitope in the M1′ segment of IgE defined by the residues 317 to 351 of SEQ ID NO:1 and with a Scatchard binding affinity that is equivalent to that of humanized anti-IgE/M1′ antibody 47H4v5.
An isolated nucleic acid encoding an anti-IgE/M1′ antibody comprising a heavy chain and light chain, wherein the heavy chain and light chain HVRs of the antibody or antigen-binding fragment thereof are selected from the group consisting of:
- 26A11, 26A11 v.1-16, 7A6, 7A6v1, 47H4, 47H4v1-6.
An isolated nucleic acid encoding an anti-IgE/M1′ antibody comprising a heavy chain and a light chain, comprising nucleic acid encoding the variable regions of the heavy or light chains of the antibody or antigen-binding fragment thereof selected from the group consisting of:
- 26A11, 26A11 v.1-16, 7A6, 7A6v1, 47H4, 47H4v1-6.
An isolated nucleic acid encoding an anti-IgE/M1 antibody, comprising either SEQ ID NO:41 or SEQ ID NO:31.
An isolated nucleic acid encoding an anti-IgE/M1′ antibody comprising a variable heavy chain a variable light chain, wherein the variable heavy chain further comprises and HVR-H1, HVR-H2 and HVR-H3, and the variable light chain further comprises an HVR-L1, HVR-2 and HVR-L3 and:
- (a) the HVR-H1 comprises residues 26-35 of SEQ ID NO:41;
- (b) the HVR-H2 comprises residues 49-66 of SEQ ID NO:41;
- (c) the HVR-H3 comprises residues 97-106 of SEQ ID NO:41;
- (d) the HVR-L1 comprises residues 24-39 of SEQ ID NO:31;
- (e) the HVR-L2 comprises residues 55-61 of SEQ ID NO:31;
- and
- (f) the HVR-L3 comprises residues 94-102 of SEQ ID NO:31.
An isolated nucleic acid encoding an anti-IgE-M1′ antibody that specifically binds an epitope in the M1′ segment of IgE defined by the residues 317 to 351 of SEQ ID NO:1.
Dependencies are inferred from the claim text.