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US 8,618,263 B2Granted
Antibodies against tissue factor pathway inhibitor (TFPI)
AssigneeNovo Nordisk A/S
InventorsIda Hilden, Jes Thorn Clausen
Life of this patent
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Abstract
The invention relates to antibodies that specifically bind to tissue factor pathway inhibitor (TFPI) and that reduce clotting time in (a) human FVIII-deficient plasma and/or (b) human whole blood. Such antibodies have utility in the treatment of bleeding disorders and in the stimulation of blood clotting.
Claims8
An isolated antibody that specifically binds to tissue factor pathway inhibitor (TFPI) comprising
- amino acids 24 to 39 of SEQ ID NO:
- 3;
- amino acids 55 to 61 of SEQ ID NO:
- 3;
- amino acids 94 to 102 of SEQ ID NO:
- 3;
- amino acids 31 to 35 of SEQ ID NO:
- 6;
- amino acids 50 to 65 of SEQ ID NO:
- 6;
- and
- amino acids 98 to 107 of SEQ ID NO:
- 6.
10 more elements
Dependencies are inferred from the claim text.