Freeze-dried fibrin matrices and methods for preparation thereof
AssigneeProChon Biotech Ltd.
InventorsAvner Yayon, Malkit Azachi, Micha Gladnikoff
Life of this patent
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Abstract
Methods for treating diseased or injured tissue by implanting into the tissue at a site of the disease or injury a porous freeze-dried fibrin matrix formed from plasma proteins. The proteins include fibrinogen cleaved by the action of thrombin at varying concentrations sufficient to cleave the fibrinogen and Factor XIII. The matrix has less than 10% residual moisture and is devoid of exogenous anti-fibrinolytic agents, plasminogen and of organic chelating agents. Alternatively, the plasma proteins comprise partially purified plasma proteins that are devoid of plasminogen.
Claims20
A method of treating diseased or injured tissue, comprising:
- implanting into the tissue at a site of disease or injury a porous freeze-dried fibrin matrix formed from plasma proteins comprising Factor XIII and fibrinogen cleaved by thrombin, wherein the matrix has less than 10% residual moisture and is devoid of exogenous anti-fibrinolytic agents, plasminogen and organic chelating agents, and wherein the diseased or injured tissue is selected from the group consisting of cartilage, bone, liver, pancreas, and cardiac tissue.
A method of treating diseased or injured tissue comprising:
- implanting into the tissue at a site of disease or injury a porous freeze-dried fibrin matrix formed from plasma proteins comprising Factor XIII and fibrinogen cleaved by thrombin, wherein the matrix has less than 10% residual moisture and is devoid of exogenous anti-fibrinolytic agents and organic chelating agents, wherein said plasma proteins are partially purified to be devoid of plasminogen and wherein the diseased or injured tissue is selected from the group consisting of cartilage, bone, liver, pancreas, and cardiac tissue.
Dependencies are inferred from the claim text.