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US 8,618,250 B2Granted
Designer collagens and use thereof
AssigneeThe Texas A&M University System
InventorsBrooke H. Russell, Magnus Hook, Mariah S. Hahn, Elizabeth M. Cosgriff-Hernandez, Neungseon Seo, Marvin Xuejun Xu
Life of this patent
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Abstract
The present invention identified a recombinant synthetic collagen containing a triple helical backbone protein produced in a prokaryotic expression system where the protein contains at least one ‘inserted’ biologically active sequence(s).
Claims18
A recombinant synthetic collagen comprising an isolated and purified protein produced in a prokaryotic expression system, wherein said protein comprises a collagen-like repeat GXYGX1Y2GX2Y2GXY SEQ ID NO:
- 13), wherein the amino acid in the X1 position is changed to L, R, or F, and/or the amino acid in the Y2 position is changed to R, K, or N, wherein the recombinant synthetic collagen forms a triple helical backbone.
Dependencies are inferred from the claim text.