Peptide, use of the peptide, method for the production of the peptide, solid support having the peptide immobilized thereon, and method for production of the solid support
AssigneesEnplas Corporation, National University Corporation Kyoto Institute of Technology
InventorsYoichi Kumada, Michimasa Kishimoto, Yuki Shiritani, Kyoko Hamasaki, Takuhito Ohse, Mitsuyasu Koike
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Abstract
Provided is a peptide containing a variable region and improved in production efficiency. The peptide contains a variable region to which an antigen-binding site is to be formed and has an amino acid sequence expressing a specific adsorption function to a solid phase at a site closer to the C-terminal than a heavy-chain variable region or at a site closer to the C-terminal than a light-chain variable region.
Claims10
A peptide, having an N-terminal and a C-terminal, said peptide comprising a first peptide region located N-terminal to a second peptide region, wherein said first peptide region is a heavy chain variable region of an antigen-binding site or a light chain variable region of an antigen-binding site, and said second peptide region has the sequence:
- 1) RIIIRRIRR (SEQ ID NO:2);
- 2) RAIARRIRR (SEQ ID NO:3);
- 3) RLLLRRLRR (SEQ ID NO:4);
- 4) RVVVRRVRR (SEQ ID NO:5);
- 5) RAAARRARR (SEQ ID NO:6);
- 6) RGGGRRGRR (SEQ ID NO:7);
- 7) RMMMRRMRR (SEQ ID NO:8);
- 8) RSSSRRSRR (SEQ ID NO:9);
- or
- 9) RTTTRRTRR (SEQ ID NO:10),
- wherein R is arginine, I is isoleucine, L is leucine, V is valine, A is alanine, G is glycine, M is methionine, S is serine and T is threonine.
Dependencies are inferred from the claim text.