Photo-activated attachment of cholesterol to polyurethane surfaces for adhesion of endothelial cells
AssigneeThe Children's Hospital of Philadelphia
InventorsRobert J. Levy, Ivan Alferiev, Stanley J. Stachelek
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Abstract
A polymer is provided according to structure I wherein Y is a thiol-reactive group and Z is an ionogenic group. The surface of a polymeric substrate is modified by contacting the surface with a polymer according to structure II or structure III and exposing the surface to ultraviolet light, optionally followed by contacting the modified surface with the polymer according to structure I.
Claims15
A polymer according to structure I
- wherein Y is a thiol-reactive group selected from one or more of the following moieties
- and Z is an ionogenic group selected from one or more of the following moieties
- and wherein n is an integer and k, m and n-k-m are each non-zero fractions of n.
A method of modifying the surface of a polymeric substrate, comprising contacting the surface of the polymeric substrate with a polymer according to structure II and/or a polymer according to structure III
- wherein n is an integer and k, m and n-k-m are each non-zero fractions of n;
- and exposing the surface to ultraviolet light;
- further comprising subsequently converting the
- moieties to —(CH2)2—SH moieties and then contacting the surface of the substrate with one or more polymers according to structure I
- wherein Y is a thiol-reactive group selected from one or more of the following moieties
- and Z is an ionogenic group selected from one or more of the following moieties
- wherein n is an integer and k, m and n-k-m are each non-zero fractions of n;
- under conditions sufficient to cause reaction of the —(CH2)2—SH moieties with the thiol-reactive groups.
A polymer according to structure III
- wherein n is an integer and k, m and n-k-m are each non-zero fractions of n.
Dependencies are inferred from the claim text.