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US 8,618,240 B2Granted
Methods and systems for generating nanoparticles
AssigneeCerulean Pharma Inc.
InventorsJohn Podobinski, J. Michael Ramstack, David S. Dickey
Life of this patent
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Abstract
In one aspect, the present invention provides a process for forming polymeric nanoparticles, which comprises using a static mixer to create a mixed flowing stream of an anti-solvent, e.g., by introducing a liquid anti-solvent into a static mixer, and introducing a polymer solution into the mixed flowing anti-solvent stream such that controlled precipitation of polymeric nanoparticles occurs. The nanoparticles can then be separated from the anti-solvent stream.
Claims42
A population of polymeric nanoparticles, comprising:
- a plurality of polymeric nanoparticles having an amphiphilic co-polymer as at least one constituent, wherein said amphiphilic co-polymer includes polylactic acid (PLA) as one of its polymeric components,
- wherein said polymeric nanoparticles exhibit an average particle size equal to or less than about 100 nm and a polydispersity index in a range of about 0.05 and about 0.1.
A population of polymeric nanoparticles, comprising:
- a plurality of polymeric nanoparticles having an amphiphilic co-polymer as at least one constituent, wherein said amphiphilic co-polymer includes polyglycolic acid (PGA) as one of its polymeric components,
- wherein said polymeric nanoparticles exhibit an average particle size equal to or less than about 100 nm and a polydispersity index in a range of about 0.05 and about 0.1.
Dependencies are inferred from the claim text.