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US 8,618,170 B2Granted
Oral formulations of bis(thiohydrazide amides)
AssigneeSynta Pharmaceuticals Corp.
InventorsNoriaki Tatsuta, Takayo Inoue, Keizo Koya
Life of this patent
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Abstract
Disclosed herein are oral formulations of bis(thio-hydrazide amides) compounds of the following structural formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R7, R8, Z, and Y are defined herein.
Claims25
A composition for oral administration comprising an effective amount of a compound represented by the following Structural Formula:
- or a pharmaceutically acceptable salt thereof, wherein:
- Y is a covalent bond or an optionally substituted straight chained hydrocarbyl group, or, Y, taken together with both >C═Z groups to which it is bonded, is an optionally substituted aromatic group;
- R1-R4 are independently —H, an optionally substituted aliphatic group, an optionally substituted aryl group, or R1 and R3 taken together with the carbon and nitrogen atoms to which they are bonded, and/or R2 and R4 taken together with the carbon and nitrogen atoms to which they are bonded, form a non-aromatic heterocyclic ring optionally fused to an aromatic ring;
- R7-R8 are independently —H, an optionally substituted aliphatic group, or an optionally substituted aryl group;
- and
- each Z is independently O or S;
- and
- one or more GRAS excipients, wherein the GRAS excipient is TPGS/PEG400.
5 more elements
A composition for oral administration comprising an effective amount of a compound represented by the following structural formula:
- wherein:
- Y′ is a covalent bond or a substituted or unsubstituted straight chained hydrocarbyl group;
- R1-R4 are independently —H, an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group, or R1 and R3 taken together with the carbon and nitrogen atoms to which they are bonded, and/or R2 and R4 taken together with the carbon and nitrogen atoms to which they are bonded, form a non-aromatic heterocyclic ring optionally fused to an aromatic ring;
- each Z is independently O or S;
- and
- M+ and M2+ are independently a pharmaceutically acceptable cations;
- and one or more GRAS excipients, wherein the GRAS excipient is TPGS/PEG400.
4 more elements
Dependencies are inferred from the claim text.